Cholinergic/Adrenergic drugs — Flashcards

Flashcard 451: Which type of acetylcholine receptors (muscarinic or nicotinic) are found in effector tissues (e.g., heart, smooth muscle, brain, and glands)?

Answer: Muscarinic

Flashcard 452: Oxybutynin and tolterodine are primarily used to treat _____

Answer: urgency incontinence (overactive bladder)

Flashcard 453: Rank the following receptors based on their affinity for dobutamine (from highest to lowest): β1, β2, α1

Answer: β1 > β2 > α1

Extra: Dobutamine is a synthetic sympathomimetic that is relatively selective for β1 receptors. Its potency at β1 is significantly greater than at β2 or α1 receptors. At clinical doses, dobutamine primarily increases cardiac contractility (inotropy) with a lesser effect on heart rate (chronotropy).

Flashcard 454: Levodopa and other Parkinson therapies are contraindicated in _____ patients

Answer: psychotic

Flashcard 455: Is phentolamine (alpha-blocker) selective or non-selective?

Answer: Non-selective

Flashcard 456: Do organophosphates (e.g. parathion) reversibly or irreversibly inhibit AChE? _____

Answer: Irreversibly (with time)

Flashcard 457: First Aid Pharmacology: Neuro/Psych Phase _____ of succinylcholine-induced neuromuscular blockade is characterized as repolarized but blocked

Answer: II

Flashcard 458: Carbidopa _____ the neuropsychiatric side effects of levodopa

Answer: exacerbates

Flashcard 459: Pilocarpine is a potent _____ of tears, sweat, and salivary secretion

Answer: stimulator

Flashcard 460: One adverse effect of anti-muscarinics (e.g. atropine) is _____ (HR)

Answer: tachycardia