Autonomic drug interactions — Flashcards

Flashcard 1: Which type of acetylcholine receptors (muscarinic or nicotinic) are found in effector tissues (e.g., heart, smooth muscle, brain, and glands)?

Answer: Muscarinic

Flashcard 2: What G-protein is the M2 muscarinic receptor coupled to? _____

Answer: Gi

Flashcard 3: In the presence of MAO inhibitors, tyramine enters the circulation and acts as a _____ agent

Answer: sympathomimetic

Flashcard 4: Organophosphate toxicity may be treated with _____, which regenerates AChE at muscarinic and nicotinic receptors if given early

Answer: pralidoxime

Flashcard 5: Phenylephrine causes _____ systolic pressure

Answer: increased

Flashcard 6: Epinephrine causes _____ diastolic pressure

Answer: decreased

Flashcard 7: Phenylephrine causes reflex _____ (HR)

Answer: bradycardia

Flashcard 8: Which **alpha-1 and alpha-2 antagonist** can be used to manage the hypertensive symptoms of **tyramine toxicity**?

Answer: Phentolamine

Flashcard 9: Does atropine reverse the flaccid paralysis associated with cholinesterase inhibitor poisoning? _____

Answer: No, only effective at muscarinic receptors

Flashcard 10: Mechanism and primary obstetric use of Terbutaline?

Answer: Select β2 agonist used as a tocolytic to delay premature labor.

Extra: Terbutaline is a selective β2-adrenergic agonist. By stimulating β2 receptors in the uterus, it causes smooth muscle relaxation, helping to suppress premature uterine contractions (tocolysis).