Cholinergic/Adrenergic drugs — Flashcards

Flashcard 1: Mechanism and primary obstetric use of Terbutaline?

Answer: Select β2 agonist used as a tocolytic to delay premature labor.

Extra: Terbutaline is a selective β2-adrenergic agonist. By stimulating β2 receptors in the uterus, it causes smooth muscle relaxation, helping to suppress premature uterine contractions (tocolysis).

Flashcard 2: Main indication and mechanism of Tamsulosin?

Answer: α1-antagonist selective for prostatic receptors (BPH treatment)

Extra: Mechanism: Inhibits smooth muscle contraction in the prostatic urethra and bladder neck. Unlike non-selective α-blockers, it has less effect on systemic blood pressure.

Flashcard 3: What is the clinical use and mechanism of Donepezil?

Answer: Used in Alzheimer's disease; Reversible Acetylcholinesterase (AChE) inhibitor

Extra: Mechanism: Centrally acting reversible acetylcholinesterase inhibitor. Indication: First-line treatment for Alzheimer's disease. Side effects: Nausea, dizziness, insomnia, bradycardia.

Flashcard 4: What is the mechanism and primary clinical use of Galantamine?

Answer: Cholinesterase inhibitor used in Alzheimer's disease

Extra: Mechanism: Reversible, competitive acetylcholinesterase inhibitor (AChEI). It may also modulate nicotinic acetylcholine receptors. Indication: Mild-to-moderate Alzheimer's disease. Side effects: Nausea, dizziness, insomnia.

Flashcard 5: What is the mechanism and primary clinical use of Rivastigmine?

Answer: Acetylcholinesterase inhibitor used in Alzheimer's disease and Parkinson's disease dementia.

Extra: Mechanisms: Reversible inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Side effects: Nausea, dizziness, insomnia. Available as a transdermal patch to reduce GI side effects.

Flashcard 6: What is the primary site of Acetylcholine (ACh) synthesis in the brain?

Answer: Nucleus basalis of Meynert (major site of synthesis)

Flashcard 7: Tubocurarine is a(n) _____ neuromuscular blocking agent

Answer: non-depolarizing

Extra:   Sketchy Pharmacology: Autonomics Watch Acetylcholinesterase Inhibitors [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-autonomic-drugs/videos/medical-pharmacology-autonomic-drugs-parasympathetic-acetylcholinesterase-inhibitors?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/neuroscience/anesthesia/acquire?ref=anki 

Flashcard 8: Echothiophate is a(n) _____ used to treat glaucoma

Answer: indirect cholinomimetic

Extra:  https://onlinemeded.org?ref=anki 

Flashcard 9: Selective α1 adrenergic antagonists (except tamsulosin) may be used to treat _____

Answer: hypertension

Extra:   Sketchy Pharmacology: Autonomics (α drugs) Watch Alpha drugs [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-autonomic-drugs/videos/medical-pharmacology-autonomic-drugs-sympathetic-alpha-drugs?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/cardiology/hypertension/acquire?ref=anki  

Flashcard 10: What catecholamine is contraindicated in closed-angle glaucoma? _____

Answer: Epinephrine (mydriatic effect worsens the glaucoma)

Extra:   https://onlinemeded.org/spa/pediatrics/ophthalmology/acquire?ref=anki Atlas: