Alpha-adrenergic agonists US Medical PG Flashcards - Medical Study Cards
Master Alpha-adrenergic agonists with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Alpha-adrenergic agonists Flashcard Deck - 10 Cards
Flashcard 1: Phenylephrine is primarily an _____ (alpha 1 or 2) agonist
Answer: 1
Flashcard 2: Activation of the alpha-1 (α1) adrenergic receptor may cause urinary _____
Answer: retention
Flashcard 3: What effect do alpha-2 agonists have on sympathetic tone?
Answer: Decreased (sympatholytic)
Flashcard 4: Tricyclic antidepressants antagonize the _____ adrenergic receptor
Answer: Alpha-1 (α1)
Flashcard 5: Mechanism and primary obstetric use of Terbutaline?
Answer: Select β2 agonist used as a tocolytic to delay premature labor.
Extra: Terbutaline is a selective β2-adrenergic agonist. By stimulating β2 receptors in the uterus, it causes smooth muscle relaxation, helping to suppress premature uterine contractions (tocolysis).
Flashcard 6: Main indication and mechanism of Tamsulosin?
Answer: α1-antagonist selective for prostatic receptors (BPH treatment)
Extra: Mechanism: Inhibits smooth muscle contraction in the prostatic urethra and bladder neck. Unlike non-selective α-blockers, it has less effect on systemic blood pressure.
Flashcard 7: What is the clinical use and mechanism of Donepezil?
Answer: Used in Alzheimer's disease; Reversible Acetylcholinesterase (AChE) inhibitor
Extra: Mechanism: Centrally acting reversible acetylcholinesterase inhibitor.
Indication: First-line treatment for Alzheimer's disease.
Side effects: Nausea, dizziness, insomnia, bradycardia.
Flashcard 8: What is the mechanism and primary clinical use of Galantamine?
Answer: Cholinesterase inhibitor used in Alzheimer's disease
Extra: Mechanism: Reversible, competitive acetylcholinesterase inhibitor (AChEI). It may also modulate nicotinic acetylcholine receptors.
Indication: Mild-to-moderate Alzheimer's disease.
Side effects: Nausea, dizziness, insomnia.
Flashcard 9: What is the mechanism and primary clinical use of Rivastigmine?
Answer: Acetylcholinesterase inhibitor used in Alzheimer's disease and Parkinson's disease dementia.
Extra: Mechanisms: Reversible inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).
Side effects: Nausea, dizziness, insomnia.
Available as a transdermal patch to reduce GI side effects.
Flashcard 10: What is the primary site of Acetylcholine (ACh) synthesis in the brain?
Answer: Nucleus basalis of Meynert (major site of synthesis)
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