Clinical applications in autonomic disorders — Flashcards

Flashcard 1: What drug class does atropine belong to? _____

Answer: Anti-muscarinics

Flashcard 2: What drug class does pilocarpine belong to? _____

Answer: Cholinomimetics (muscarinic agonists)

Flashcard 3: What is the predominant autonomic receptor on the ciliary muscle? _____

Answer: M3

Flashcard 4: Trazodone is an _____-adrenergic antagonist

Answer: α1 (Alpha-1)

Extra: Trazodone's α1-adrenergic antagonism is responsible for side effects such as orthostatic hypotension and priapism (mnemonic: trazoBONE).

Flashcard 5: What drug class does bethanechol belong to? _____

Answer: Cholinomimetics (muscarinic agonists)

Flashcard 6: Mirtazapine is a selective _____ adrenergic antagonist

Answer: alpha-2

Flashcard 7: Which **alpha-1 and alpha-2 antagonist** can be used to manage the hypertensive symptoms of **tyramine toxicity**?

Answer: Phentolamine

Flashcard 8: Mechanism and primary obstetric use of Terbutaline?

Answer: Select β2 agonist used as a tocolytic to delay premature labor.

Extra: Terbutaline is a selective β2-adrenergic agonist. By stimulating β2 receptors in the uterus, it causes smooth muscle relaxation, helping to suppress premature uterine contractions (tocolysis).

Flashcard 9: Main indication and mechanism of Tamsulosin?

Answer: α1-antagonist selective for prostatic receptors (BPH treatment)

Extra: Mechanism: Inhibits smooth muscle contraction in the prostatic urethra and bladder neck. Unlike non-selective α-blockers, it has less effect on systemic blood pressure.

Flashcard 10: What is the clinical use and mechanism of Donepezil?

Answer: Used in Alzheimer's disease; Reversible Acetylcholinesterase (AChE) inhibitor

Extra: Mechanism: Centrally acting reversible acetylcholinesterase inhibitor. Indication: First-line treatment for Alzheimer's disease. Side effects: Nausea, dizziness, insomnia, bradycardia.