Beta-adrenergic antagonists — Flashcards

Flashcard 1: Terazosin is a _____ receptor antagonist used to treat BPH in patients with hypertension

Answer: α1 (alpha-1)

Flashcard 2: Trazodone is an _____-adrenergic antagonist

Answer: α1 (Alpha-1)

Extra: Trazodone's α1-adrenergic antagonism is responsible for side effects such as orthostatic hypotension and priapism (mnemonic: trazoBONE).

Flashcard 3: Which two beta-blockers have partial agonist activity? _____

Answer: Acebutolol and pindolol

Flashcard 4: Beta Blockers are used to treat _____ by blocking the hyperadrenergic symptoms

Answer: Thyrotoxicosis (thyroid storm)

Flashcard 5: What adverse effect may pseudoephedrine and phenylephrine have on blood pressure? _____

Answer: Increased BP (Hypertension)

Flashcard 6: Phenylephrine causes reflex _____ (HR)

Answer: bradycardia

Flashcard 7: Mechanism and primary obstetric use of Terbutaline?

Answer: Select β2 agonist used as a tocolytic to delay premature labor.

Extra: Terbutaline is a selective β2-adrenergic agonist. By stimulating β2 receptors in the uterus, it causes smooth muscle relaxation, helping to suppress premature uterine contractions (tocolysis).

Flashcard 8: Main indication and mechanism of Tamsulosin?

Answer: α1-antagonist selective for prostatic receptors (BPH treatment)

Extra: Mechanism: Inhibits smooth muscle contraction in the prostatic urethra and bladder neck. Unlike non-selective α-blockers, it has less effect on systemic blood pressure.

Flashcard 9: What is the clinical use and mechanism of Donepezil?

Answer: Used in Alzheimer's disease; Reversible Acetylcholinesterase (AChE) inhibitor

Extra: Mechanism: Centrally acting reversible acetylcholinesterase inhibitor. Indication: First-line treatment for Alzheimer's disease. Side effects: Nausea, dizziness, insomnia, bradycardia.

Flashcard 10: What is the mechanism and primary clinical use of Galantamine?

Answer: Cholinesterase inhibitor used in Alzheimer's disease

Extra: Mechanism: Reversible, competitive acetylcholinesterase inhibitor (AChEI). It may also modulate nicotinic acetylcholine receptors. Indication: Mild-to-moderate Alzheimer's disease. Side effects: Nausea, dizziness, insomnia.