Sympathomimetics — Flashcards

Flashcard 1: Phenylephrine is primarily an _____ (alpha 1 or 2) agonist

Answer: 1

Flashcard 2: Alpha-antagonists (e.g., phentolamine) can be used to treat _____ (illicit drug) toxicity.

Answer: Cocaine

Flashcard 3: Rank the following receptors for affinity to **norepinephrine**, from highest to lowest: α1, β1, β2

Answer: α1 > β1 > β2

Extra: Norepinephrine is a potent agonist at α1, α2, and β1 receptors, but has negligible activity at β2 receptors. Contrast this with Epinephrine, which has significant activity at all four receptors (α1, α2, β1, β2).

Flashcard 4: What type of adrenergic receptor is found on the renal afferent and efferent arterioles? _____

Answer: Alpha-1 adrenergic receptors

Flashcard 5: In the presence of MAO inhibitors, tyramine enters the circulation and acts as a _____ agent

Answer: sympathomimetic

Flashcard 6: Beta Blockers are used to treat _____ by blocking the hyperadrenergic symptoms

Answer: Thyrotoxicosis (thyroid storm)

Flashcard 7: Methylphenidate is an amphetamine derivative used to treat _____

Answer: ADHD

Flashcard 8: Tricyclic antidepressants antagonize the _____ adrenergic receptor

Answer: Alpha-1 (α1)

Flashcard 9: What catecholamine may be administered to treat acute, severe asthma exacerbation? _____

Answer: Epinephrine

Flashcard 10: Mechanism and primary obstetric use of Terbutaline?

Answer: Select β2 agonist used as a tocolytic to delay premature labor.

Extra: Terbutaline is a selective β2-adrenergic agonist. By stimulating β2 receptors in the uterus, it causes smooth muscle relaxation, helping to suppress premature uterine contractions (tocolysis).