Muscarinic antagonists — Flashcards

Flashcard 1: One adverse effect of anti-muscarinics is _____, especially in men with prostatic hyperplasia

Answer: urinary retention

Flashcard 2: The vestibular system contains _____ muscarinic receptors

Answer: M1

Flashcard 3: Which anti-muscarinic (tiotropium or ipratropium) is longer-acting? _____

Answer: Tiotropium

Flashcard 4: The _____ muscarinic receptor is found in glands, the bladder, and smooth muscle

Answer: M3

Flashcard 5: Which "DUMBBELSS" symptom is NOT alleviated by atropine administration in cholinesterase inhibitor poisoning?_____

Answer: Excitation of skeletal muscle and CNS

Flashcard 6: Does atropine reverse the flaccid paralysis associated with cholinesterase inhibitor poisoning? _____

Answer: No, only effective at muscarinic receptors

Flashcard 7: Mechanism and primary obstetric use of Terbutaline?

Answer: Select β2 agonist used as a tocolytic to delay premature labor.

Extra: Terbutaline is a selective β2-adrenergic agonist. By stimulating β2 receptors in the uterus, it causes smooth muscle relaxation, helping to suppress premature uterine contractions (tocolysis).

Flashcard 8: Main indication and mechanism of Tamsulosin?

Answer: α1-antagonist selective for prostatic receptors (BPH treatment)

Extra: Mechanism: Inhibits smooth muscle contraction in the prostatic urethra and bladder neck. Unlike non-selective α-blockers, it has less effect on systemic blood pressure.

Flashcard 9: What is the clinical use and mechanism of Donepezil?

Answer: Used in Alzheimer's disease; Reversible Acetylcholinesterase (AChE) inhibitor

Extra: Mechanism: Centrally acting reversible acetylcholinesterase inhibitor. Indication: First-line treatment for Alzheimer's disease. Side effects: Nausea, dizziness, insomnia, bradycardia.

Flashcard 10: What is the mechanism and primary clinical use of Galantamine?

Answer: Cholinesterase inhibitor used in Alzheimer's disease

Extra: Mechanism: Reversible, competitive acetylcholinesterase inhibitor (AChEI). It may also modulate nicotinic acetylcholine receptors. Indication: Mild-to-moderate Alzheimer's disease. Side effects: Nausea, dizziness, insomnia.