Cholinergic/Adrenergic drugs — Flashcards

Flashcard 321: Phenylephrine causes reflex _____ (HR)

Answer: bradycardia

Flashcard 322: Glycopyrrolate is a(n) _____ antagonist

Answer: Muscarinic

Extra: Glycopyrrolate is a **non-selective** muscarinic antagonist. It is a **quaternary ammonium** compound, meaning it does not cross the blood-brain barrier and has minimal CNS side effects (unlike atropine). It is often used to reduce secretions (antisialogogue) and to prevent bradycardia during the reversal of neuromuscular blockade.

Flashcard 323: Is phentolamine (alpha-blocker) reversible or irreversible?

Answer: Reversible

Flashcard 324: What sensation is lost first with local anesthetics? _____

Answer: Pain

Flashcard 325: First Aid Pharmacology: Neuro/Psych MAO inhibitors are contraindicated in patients taking _____, which is a medicinal herb with antidepressant activity

Answer: St. John's wort

Flashcard 326: Organophosphate toxicity may be treated with _____, which regenerates AChE at muscarinic and nicotinic receptors if given early

Answer: pralidoxime

Flashcard 327: What drug class do galantamine and tacrine belong to?_____

Answer: Acetylcholinesterase inhibitors

Flashcard 328: During phase I blockade using depolarizing NMJ blockers, TOF stimulation shows _____ of all four twitches

Answer: equal reduction

Flashcard 329: Indirect cholinomimetics exert their effects via inhibition of the enzyme _____

Answer: acetylcholinesterase (AChE)

Flashcard 330: What G-protein is the M2 muscarinic receptor coupled to? _____

Answer: Gi