Cholinergic/Adrenergic drugs — Flashcards

Flashcard 281: What drug class do neostigmine, physostigmine, and pyridostigmine belong to?_____

Answer: Acetylcholinesterase inhibitors

Flashcard 282: Does atropine reverse the flaccid paralysis associated with cholinesterase inhibitor poisoning? _____

Answer: No, only effective at muscarinic receptors

Flashcard 283: The detrusor muscle predominantly expresses _____ receptors.

Answer: M3 and B3

Flashcard 284: Compared to other antidepressants, bupropion is _____ likely to cause weight gain

Answer: less

Flashcard 285: Long-acting beta-2 agonists are used for _____ in moderate or severe persistent asthma

Answer: prophylaxis

Flashcard 286: Adverse effects of paroxetine include anti-_____ effects, sleep disturbances (abnormal dreams), and sexual dysfunction

Answer: cholinergic

Extra: Paroxetine is unique among SSRIs for having significant anticholinergic activity. While most SSRIs primarily cause GI upset (nausea), sexual dysfunction, and sleep disturbances, paroxetine's side effect profile also includes dry mouth and constipation due to its muscarinic antagonism. Note: Vortioxetine (the drug previously listed on this card) is an atypical antidepressant that lacks significant anticholinergic effects and is most commonly associated with nausea.

Flashcard 287: Mirabegron is indicated for _____

Answer: urinary urge incontinence

Flashcard 288: Tolcapone can cause _____ failure as an adverse effect

Answer: hepatic

Flashcard 289: Phenylephrine causes _____ systolic pressure

Answer: increased

Flashcard 290: Compared to typical antipsychotics, atypical antipsychotics are _____ likely to cause extrapyramidal symptoms (EPS)

Answer: less