Autonomic/CV Drugs — Flashcards

Flashcard 2651: Which chemotherapeutic drug is widely used for the prophylaxis of organ/graft rejection?

Answer: Azathioprine (6-MP)

Flashcard 2652: Do nonbenzodiazepine hypnotics cause significant day-after psychomotor depression and/or amnesia? _____

Answer: No

Flashcard 2653: Triptans _____ release of vasoactive peptides

Answer: prevent

Flashcard 2654: Class IV antiarrhythmics are useful in preventing _____ in atrial fibrillation and flutter ("rate control")

Answer: rapid ventricular response (RVR)

Flashcard 2655: Typical antipsychotics may cause symptoms of _____ excess (e.g. galactorrhea, amenorrhea, gynecomastia)

Answer: prolactin

Flashcard 2656: _____ is an antagonist at breast and uterus and an agonist at bone

Answer: Raloxifene

Flashcard 2657: VEGF RTK inhibitors can cause hyper_____

Answer: tension

Extra: VEGF RTK inhibitors (e.g., sunitinib, sorafenib) and VEGF antibodies (e.g., bevacizumab) commonly cause **hypertension** by decreasing nitric oxide production in the vascular endothelium. Note: While RTK inhibitors specifically can also cause a **hand-foot skin reaction** (characterized by hyperkeratosis), hypertension is the hallmark cardiovascular side effect and aligns with the topic categorization.

Flashcard 2658: What drug class does lidocaine belong to? _____

Answer: Class IB antiarrhythmics

Flashcard 2659: Glucocorticoids are useful for _____ therapy (e.g. transplant rejection prevention, treatment of autoimmune disorders)

Answer: immunosuppressive

Flashcard 2660: _____ are first line agents for treatment of acute gout, as they block prostaglandin synthesis at COX

Answer: NSAIDs (ie: indomethacin)