Peripheral vascular disease therapies US Medical PG Flashcards - Medical Study Cards
Master Peripheral vascular disease therapies with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Peripheral vascular disease therapies Flashcard Deck - 10 Cards
Flashcard 1: Dyslipidemia drugs _____ are the only lipid-lowering drugs consistently proven to reduce risk of atherosclerotic heart disease
Answer: Statins
Flashcard 2: Do ADP receptor inhibitors reduce symptoms of claudication in peripheral artery disease? _____
Answer: No
Flashcard 3: Treatment of acute coronary syndromes often includes an _____ receptor inhibitor such as clopidogrel
Answer: ADP
Flashcard 4: What drug class does cilostazol belong to?_____
Answer: antiplatelet PDE-3 inhibitor
Flashcard 5: In addition to preventing platelet aggregation, cilostazol and dipyridamole also cause vaso-_____
Answer: dilation
Flashcard 6: vardenafil
Answer: PDE5 inhibitor
Extra: erectile dysfunctionpatients taking nitrates (lethal hypotension)inhbit phosphodiesterase 5, resulting in increased cGMP and smooth muscle relaxation in corpus cavernosumheadache, flushing, impaired blue-green color vision, hypotension, dyspepsia
Flashcard 7: sildenafil
Answer: PDE5 inhibitor
Extra: erectile dysfunctionpatients taking nitrates (lethal hypotension)inhbit phosphodiesterase 5, resulting in increased cGMP and smooth muscle relaxation in corpus cavernosumheadache, flushing, impaired blue-green color vision, hypotension, dyspepsia
Flashcard 8: What is the effect of high-dose Aspirin (salicylates) on oxidative phosphorylation?
Answer: Uncouples oxidative phosphorylation (increases permeability of the inner mitochondrial membrane)
Extra: Aspirin (salicylates) in high doses uncouples oxidative phosphorylation, leading to a decreased ATP production and increased heat production (fever). It also contributes to the metabolic acidosis seen in salicylate toxicity.
Flashcard 9: Mechanism of action of Ouabain?
Answer: Inhibits Na+/K+-ATPase by binding to the K+ binding site
Extra: Ouabain is a cardiac glycoside (similar to digoxin) that binds to the extracellular side of the Na+/K+-ATPase pump, competing with Potassium (K+). This leads to increased intracellular Na+, which in turn decreases the activity of the Na+/Ca2+ exchanger, resulting in increased intracellular Ca2+ and positive inotropy.
Flashcard 10: Ischemic priapism is treated with corporal aspiration, intracavernosal _____, or surgical decompression to prevent ischemia
Answer: phenylephrine
Extra:
https://onlinemeded.org?ref=anki
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