Vasopressors and inotropes US Medical PG Flashcards - Medical Study Cards
Master Vasopressors and inotropes with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Vasopressors and inotropes Flashcard Deck - 10 Cards
Flashcard 1: Desmopressin (DDAVP) has high specificity for the ADH-activated _____ receptor
Answer: V2
Flashcard 2: Alpha-receptor antagonists may cause reflex _____ (HR) as an adverse effect
Answer: tachycardia
Flashcard 3: Milrinone and inamrinone are _____ inhibitors used in the treatment of acute heart failure
Answer: PDE-3
Flashcard 4: What sympathomimetic is used to treat cardiogenic shock? _____
Answer: Dobutamine
Flashcard 5: What catecholamine is used to treat anaphylactic shock? _____
Answer: Epinephrine
Flashcard 6: Activation of the _____ histamine receptor may cause pain, pruritus, and vasodilation
Answer: H1
Flashcard 7: vardenafil
Answer: PDE5 inhibitor
Extra: erectile dysfunctionpatients taking nitrates (lethal hypotension)inhbit phosphodiesterase 5, resulting in increased cGMP and smooth muscle relaxation in corpus cavernosumheadache, flushing, impaired blue-green color vision, hypotension, dyspepsia
Flashcard 8: sildenafil
Answer: PDE5 inhibitor
Extra: erectile dysfunctionpatients taking nitrates (lethal hypotension)inhbit phosphodiesterase 5, resulting in increased cGMP and smooth muscle relaxation in corpus cavernosumheadache, flushing, impaired blue-green color vision, hypotension, dyspepsia
Flashcard 9: What is the effect of high-dose Aspirin (salicylates) on oxidative phosphorylation?
Answer: Uncouples oxidative phosphorylation (increases permeability of the inner mitochondrial membrane)
Extra: Aspirin (salicylates) in high doses uncouples oxidative phosphorylation, leading to a decreased ATP production and increased heat production (fever). It also contributes to the metabolic acidosis seen in salicylate toxicity.
Flashcard 10: Mechanism of action of Ouabain?
Answer: Inhibits Na+/K+-ATPase by binding to the K+ binding site
Extra: Ouabain is a cardiac glycoside (similar to digoxin) that binds to the extracellular side of the Na+/K+-ATPase pump, competing with Potassium (K+). This leads to increased intracellular Na+, which in turn decreases the activity of the Na+/Ca2+ exchanger, resulting in increased intracellular Ca2+ and positive inotropy.
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