Phosphodiesterase inhibitors — Flashcards

Flashcard 1: In addition to erectile dysfunction, sildenafil may also be used to treat _____

Answer: pulmonary hypertension

Flashcard 2: PDE-5 inhibitors (e.g. sildenafil, tadalafil) are indicated for _____ hypertension

Answer: pulmonary

Flashcard 3: Milrinone and inamrinone are _____ inhibitors used in the treatment of acute heart failure

Answer: PDE-3

Flashcard 4: ACE inhibitors, Beta-blockers (compensated HF), and Aldosterone Antagonists are beneficial in Heart Failure because they help prevent:

Answer: Cardiac remodeling

Extra: These drug classes (ACE inhibitors, Beta-blockers, and Aldosterone Antagonists) have been shown to reduce mortality in patients with heart failure by preventing or reversing maladaptive cardiac remodeling.

Flashcard 5: What drug class do vardenafil, tadalafil, and sildenafil belong to?_____

Answer: PDE-5 inhibitors

Flashcard 6: vardenafil

Answer: PDE5 inhibitor

Extra: erectile dysfunctionpatients taking nitrates (lethal hypotension)inhbit phosphodiesterase 5, resulting in increased cGMP and smooth muscle relaxation in corpus cavernosumheadache, flushing, impaired blue-green color vision, hypotension, dyspepsia

Flashcard 7: sildenafil

Answer: PDE5 inhibitor

Extra: erectile dysfunctionpatients taking nitrates (lethal hypotension)inhbit phosphodiesterase 5, resulting in increased cGMP and smooth muscle relaxation in corpus cavernosumheadache, flushing, impaired blue-green color vision, hypotension, dyspepsia

Flashcard 8: What is the effect of high-dose Aspirin (salicylates) on oxidative phosphorylation?

Answer: Uncouples oxidative phosphorylation (increases permeability of the inner mitochondrial membrane)

Extra: Aspirin (salicylates) in high doses uncouples oxidative phosphorylation, leading to a decreased ATP production and increased heat production (fever). It also contributes to the metabolic acidosis seen in salicylate toxicity.

Flashcard 9: Mechanism of action of Ouabain?

Answer: Inhibits Na+/K+-ATPase by binding to the K+ binding site

Extra: Ouabain is a cardiac glycoside (similar to digoxin) that binds to the extracellular side of the Na+/K+-ATPase pump, competing with Potassium (K+). This leads to increased intracellular Na+, which in turn decreases the activity of the Na+/Ca2+ exchanger, resulting in increased intracellular Ca2+ and positive inotropy.

Flashcard 10: Ischemic priapism is treated with corporal aspiration, intracavernosal _____, or surgical decompression to prevent ischemia

Answer: phenylephrine

Extra:  https://onlinemeded.org?ref=anki