Class I antiarrhythmics (sodium channel blockers) — Flashcards

Flashcard 1: What drug class does quinidine belong to? _____

Answer: Class IA antiarrhythmics

Flashcard 2: What effect do class I antiarrhythmics have on the action potentials of the SA and AV nodes?_____

Answer: No effect (only affects Na+-dependent action potentials)

Flashcard 3: In addition to Na+ channels, Class IA antiarrhythmics also block _____ channels

Answer: K+

Flashcard 4: What type of drug are class II antiarrhythmics? _____

Answer: Beta-blockers

Flashcard 5: What type of drug are class IV antiarrhythmics? _____

Answer: Non-dihydropyridine Ca2+ channel blockers

Flashcard 6: What drug class does mexiletine belong to? _____

Answer: Class IB antiarrhythmics

Flashcard 7: Which classes (2) of antiarrhythmics are used for rhythm control in atrial fibrillation and flutter?_____

Answer: Class IC and III

Flashcard 8: vardenafil

Answer: PDE5 inhibitor

Extra: erectile dysfunctionpatients taking nitrates (lethal hypotension)inhbit phosphodiesterase 5, resulting in increased cGMP and smooth muscle relaxation in corpus cavernosumheadache, flushing, impaired blue-green color vision, hypotension, dyspepsia

Flashcard 9: sildenafil

Answer: PDE5 inhibitor

Extra: erectile dysfunctionpatients taking nitrates (lethal hypotension)inhbit phosphodiesterase 5, resulting in increased cGMP and smooth muscle relaxation in corpus cavernosumheadache, flushing, impaired blue-green color vision, hypotension, dyspepsia

Flashcard 10: What is the effect of high-dose Aspirin (salicylates) on oxidative phosphorylation?

Answer: Uncouples oxidative phosphorylation (increases permeability of the inner mitochondrial membrane)

Extra: Aspirin (salicylates) in high doses uncouples oxidative phosphorylation, leading to a decreased ATP production and increased heat production (fever). It also contributes to the metabolic acidosis seen in salicylate toxicity.