Antianginal drugs US Medical PG Flashcards - Medical Study Cards
Master Antianginal drugs with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Antianginal drugs Flashcard Deck - 10 Cards
Flashcard 1: ACE inhibitors are first line agents in the treatment of heart _____
Answer: failure
Extra:
FA2020 UPDATE: ACE inhibitors dilate the efferent arteriole, not constrict as the image below states:
Sketchy Pharmacology: Cardiovascular/Renal
Watch ACE inhibitors, ARBs, Aliskiren [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-cardiovascular-renal/videos/medical-pharmacology-cardiovascular-and-renal-heart-failure-drugs-ace-inhibitors-arbs-aliskiren?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch associated Bootcamp video [https://app.bootcamp.com/med-school/cardiology/videos/renin-angiotensin-aldosterone-system?index=4]
https://onlinemeded.org/spa/cardiology/heart-failure/acquire?ref=anki
Flashcard 2: Adverse effects associated with nitrates include _____ and syncope due to pooling of blood in veins
Answer: orthostatic hypotension
Flashcard 3: What type of beta-blocker is metoprolol?
Answer: Selective beta-1 antagonist (cardioselective)
Flashcard 4: What is the effect of combined nitrates and β-blockers on heart rate?
Answer: No effect or decreased
Flashcard 5: One adverse effect associated with Ca2+ channel blockers (e.g. verapamil) is _____ hyperplasia
Answer: gingival
Flashcard 6: Treatment of acute coronary syndromes often includes _____, which decrease heart rate and reduce risk of arrhythmia
Answer: Beta-blockers
Flashcard 7: vardenafil
Answer: PDE5 inhibitor
Extra: erectile dysfunction patients taking nitrates (lethal hypotension) inhbit phosphodiesterase 5, resulting in increased cGMP and smooth muscle relaxation in corpus cavernosum headache, flushing, impaired blue-green color vision, hypotension, dyspepsia
Flashcard 8: sildenafil
Answer: PDE5 inhibitor
Extra: erectile dysfunction patients taking nitrates (lethal hypotension) inhbit phosphodiesterase 5, resulting in increased cGMP and smooth muscle relaxation in corpus cavernosum headache, flushing, impaired blue-green color vision, hypotension, dyspepsia
Flashcard 9: What is the effect of high-dose Aspirin (salicylates) on oxidative phosphorylation?
Answer: Uncouples oxidative phosphorylation (increases permeability of the inner mitochondrial membrane)
Extra: Aspirin (salicylates) in high doses uncouples oxidative phosphorylation, leading to a decreased ATP production and increased heat production (fever). It also contributes to the metabolic acidosis seen in salicylate toxicity.
Flashcard 10: Mechanism of action of Ouabain?
Answer: Inhibits Na+/K+-ATPase by binding to the K+ binding site
Extra: Ouabain is a cardiac glycoside (similar to digoxin) that binds to the extracellular side of the Na+/K+-ATPase pump, competing with Potassium (K+). This leads to increased intracellular Na+, which in turn decreases the activity of the Na+/Ca2+ exchanger, resulting in increased intracellular Ca2+ and positive inotropy.
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