Cardiac glycosides US Medical PG Flashcards - Medical Study Cards
Master Cardiac glycosides with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Cardiac glycosides Flashcard Deck - 10 Cards
Flashcard 1: Cardiac glycosides (e.g. digoxin) exert their effects via inhibition of the _____ pump
Answer: Na+-K+ ATPase
Flashcard 2: Magnesium may be used as an antiarrhythmic to treat _____ toxicity
Answer: digoxin
Flashcard 3: What class of drugs directly inhibit the Na+-K+ ATPase pump?_____
Answer: Cardiac glycosides (e.g. digoxin)
Flashcard 4: One factor that predisposes to digoxin toxicity is _____ insufficiency, which decreases drug excretion
Answer: renal
Flashcard 5: Digoxin is useful in the treatment of _____ fibrillation (and flutter)
Answer: atrial
Flashcard 6: vardenafil
Answer: PDE5 inhibitor
Extra: erectile dysfunctionpatients taking nitrates (lethal hypotension)inhbit phosphodiesterase 5, resulting in increased cGMP and smooth muscle relaxation in corpus cavernosumheadache, flushing, impaired blue-green color vision, hypotension, dyspepsia
Flashcard 7: sildenafil
Answer: PDE5 inhibitor
Extra: erectile dysfunctionpatients taking nitrates (lethal hypotension)inhbit phosphodiesterase 5, resulting in increased cGMP and smooth muscle relaxation in corpus cavernosumheadache, flushing, impaired blue-green color vision, hypotension, dyspepsia
Flashcard 8: What is the effect of high-dose Aspirin (salicylates) on oxidative phosphorylation?
Answer: Uncouples oxidative phosphorylation (increases permeability of the inner mitochondrial membrane)
Extra: Aspirin (salicylates) in high doses uncouples oxidative phosphorylation, leading to a decreased ATP production and increased heat production (fever). It also contributes to the metabolic acidosis seen in salicylate toxicity.
Flashcard 9: Mechanism of action of Ouabain?
Answer: Inhibits Na+/K+-ATPase by binding to the K+ binding site
Extra: Ouabain is a cardiac glycoside (similar to digoxin) that binds to the extracellular side of the Na+/K+-ATPase pump, competing with Potassium (K+). This leads to increased intracellular Na+, which in turn decreases the activity of the Na+/Ca2+ exchanger, resulting in increased intracellular Ca2+ and positive inotropy.
Flashcard 10: Ischemic priapism is treated with corporal aspiration, intracavernosal _____, or surgical decompression to prevent ischemia
Answer: phenylephrine
Extra:
https://onlinemeded.org?ref=anki
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