Autonomic/CV Drugs — Flashcards

Flashcard 2181: Do most NSAIDs inhibit COX-1 or COX-2?_____

Answer: Both

Flashcard 2182: Sodium Bicarbonate is used to treat drug overdoses that are caused by drugs that are weak _____

Answer: acids

Flashcard 2183: Sirolimus and cyclosporine are _____ when given with each other

Answer: synergistic (pharmacological property)

Flashcard 2184: Which generation of H1 histamine receptor antagonists are used to treat allergies? _____

Answer: Both 1st and 2nd generation

Flashcard 2185: What is a possible skin complication associated with amiodarone?

Answer: Blue-gray skin discoloration (hyperpigmentation)

Extra: Amiodarone is a class III antiarrhythmic. It is associated with several high-yield side effects: - **Pulmonary fibrosis** (most serious) - **Thyroid dysfunction** (hypo- or hyperthyroidism, due to its high iodine content) - **Hepatotoxicity** - **Corneal microdeposits** - **Blue-gray skin discoloration** (photodermatitis resulting in hyperpigmentation)

Flashcard 2186: Class III antiarrhythmics may be used to treat _____ fibrillation (and flutter)

Answer: atrial

Flashcard 2187: What effect do thiazide diuretics have on serum Ca2+ levels? _____

Answer: Increased

Flashcard 2188: Digoxin is derived from the _____ plant

Answer: foxglove

Flashcard 2189: Erlotinib therapy is associated with _____ and diarrhea (adverse effects)

Answer: acneiform skin rash

Flashcard 2190: Clomiphene results in _____ release of FSH and LH from the pituitary

Answer: increased