Autonomic/CV Drugs — Flashcards

Flashcard 2181: Class I antiarrhythmics exert their actions by blocking _____ channels

Answer: Na+

Flashcard 2182: What drug class do gemfibrozil and fenofibrate belong to? _____

Answer: Fibrates

Flashcard 2183: β1 selective antagonists primarily suppress adrenergic stimulation of the _____

Answer: heart (cardioselective)

Flashcard 2184: What osteoporosis drug has side effects that include acid reflux, esophagitis, and esophageal ulcers?_____

Answer: Bisphosphonates (oral)

Flashcard 2185: What is a possible skin complication associated with amiodarone?

Answer: Blue-gray skin discoloration (hyperpigmentation)

Extra: Amiodarone is a class III antiarrhythmic. It is associated with several high-yield side effects: - **Pulmonary fibrosis** (most serious) - **Thyroid dysfunction** (hypo- or hyperthyroidism, due to its high iodine content) - **Hepatotoxicity** - **Corneal microdeposits** - **Blue-gray skin discoloration** (photodermatitis resulting in hyperpigmentation)

Flashcard 2186: What effect do class IC antiarrhythmics have on the effective refractory period in the AV node and accessory bypass tracts?_____

Answer: Significant prolongation of ERP

Flashcard 2187: Patients on sulfonylureas are at increased risk of hypoglycemia if they have _____ failure

Answer: renal

Flashcard 2188: Which $\mu$-opioid antagonist is used to maintain abstinence in opioid addicts after detoxification?

Answer: Naltrexone

Flashcard 2189: Erlotinib therapy is associated with _____ and diarrhea (adverse effects)

Answer: acneiform skin rash

Flashcard 2190: In general, prostaglandins cause vaso-_____

Answer: dilation