Autonomic/CV Drugs — Flashcards

Flashcard 2191: Because the skin has abundant EGFR, patients undergoing Cetuximab treatment can experience a _____ rash

Answer: Papulopustular acneiform

Flashcard 2192: Tricyclic antidepressants antagonize the _____ histamine receptor

Answer: H1

Flashcard 2193: What is a possible skin complication associated with amiodarone?

Answer: Blue-gray skin discoloration (hyperpigmentation)

Extra: Amiodarone is a class III antiarrhythmic. It is associated with several high-yield side effects: - **Pulmonary fibrosis** (most serious) - **Thyroid dysfunction** (hypo- or hyperthyroidism, due to its high iodine content) - **Hepatotoxicity** - **Corneal microdeposits** - **Blue-gray skin discoloration** (photodermatitis resulting in hyperpigmentation)

Flashcard 2194: Reslizumab and Mepolizumab are monoclonal antibodies against _____ used for maintenance therapy for asthma.

Answer: IL-5

Flashcard 2195: Erlotinib therapy is associated with _____ and diarrhea (adverse effects)

Answer: acneiform skin rash

Flashcard 2196: What effect do thiazide diuretics have on serum Ca2+ levels? _____

Answer: Increased

Flashcard 2197: What effect do class IC antiarrhythmics have on the effective refractory period in the AV node and accessory bypass tracts?_____

Answer: Significant prolongation of ERP

Flashcard 2198: In general, prostaglandins cause vaso-_____

Answer: dilation

Flashcard 2199: What dermatologic complication is associated with carbamazepine use? _____

Answer: Stevens-Johnson syndrome

Flashcard 2200: What is the most common cause of death in tricyclic antidepressant overdose? _____

Answer: Fatal cardiac arrhythmia