Autonomic/CV Drugs — Flashcards

Flashcard 2171: Sunitinib and sorafenib are associated with an increased risk of _____

Answer: hemorrhage and hyperkeratosis (hand-foot skin reaction)

Extra: Sunitinib and sorafenib are multi-kinase inhibitors (targeting VEGFR, PDGFR, and c-KIT). High-yield side effects include hypertension, hemorrhage, and hyperkeratotic skin reactions (hand-foot syndrome). Note: Sunitinib is also associated with a yellow skin discoloration and hair depigmentation.

Flashcard 2172: Which kinase inhibitor can be used to treat non-small cell lung cancer (NSCLC) with EGFR mutations?

Answer: Erlotinib

Flashcard 2173: benzodiazepines (e.g. midazolam) may be used to create a state of _____ for minor procedures and surgeries (e.g. colonoscopy, endoscopy)

Answer: conscious sedation

Flashcard 2174: Which gout drug binds tubulin and inhibits intracellular microtubule polymerization?_____

Answer: Colchicine

Flashcard 2175: Loop diuretics may cause _____-calcemia as an adverse effect

Answer: hypo

Flashcard 2176: Glulisine, aspart, and lispro (rapid acting insulin) are useful for controlling the _____ glucose spike

Answer: postprandial

Flashcard 2177: Which anticoagulant, warfarin or heparin, may be used in the setting of an acute MI? _____

Answer: Heparin

Flashcard 2178: Adenosine may cause transient high grade _____ due to direct AV node inhibition

Answer: heart block

Flashcard 2179: Side effects of metoclopramide include extrapyramidal effects such as dystonia, akathisia, and _____ features as a result of central D2 blockade

Answer: parkinsonian

Flashcard 2180: Which classes of diuretics (2) are characterized by increased urine K+? _____

Answer: Loop and thiazide diuretics