Autonomic/CV Drugs — Flashcards

Flashcard 1721: How do sulfonylurea drugs (e.g., tolbutamide, glyburide) cause increased insulin secretion?

Answer: By closing the ATP-dependent K+ channels, causing depolarization and subsequent insulin release

Flashcard 1722: _____ is a long-acting partial μ-opioid agonist used to attenuate opioid withdrawal symptoms.

Answer: Buprenorphine

Flashcard 1723: Cocaine and amphetamine intoxication cause pupillary _____

Answer: dilation

Flashcard 1724: Alprostadil and Misoprostol are analogues of _____

Answer: PGE1

Extra: • **PGE1 analogues**: Alprostadil, Misoprostol, Gemeprost, Lubiprostone • **PGE2 analogues**: Dinoprostone • **PGF2α analogues**: Dinoprost, Carboprost, Latanoprost, Bimatoprost • **PGI2 (Prostacyclin) analogues**: Epoprostenol, Iloprost, Treprostinil

Flashcard 1725: Do oral direct thrombin inhibitors (e.g., dabigatran) require routine lab monitoring?

Answer: No

Flashcard 1726: Selegiline and rasagiline may _____ the adverse effects of levodopa

Answer: exacerbate

Flashcard 1727: Is eszopiclone (nonbenzodiazepine hypnotic) useful for sleep onset or sleep maintenance? _____

Answer: Both

Flashcard 1728: Cardiovascular (Antiarrhythmics) _____, a class III antiarrhythmic, has many neurologic side effects (e.g. tremor, ataxia, peripheral neuropathy, sleep disturbances)

Answer: Amiodarone

Flashcard 1729: Phase _____ of clinical trials confirms efficacy compared to the standard of care, as well as adverse effects

Answer: III

Flashcard 1730: Pioglitazone and rosiglitazone are examples of glitazones, also known as _____

Answer: thiazolidinediones