Autonomic/CV Drugs — Flashcards

Flashcard 1731: Decreased cAMP as a result of class II antiarrhythmics (beta-blockers) leads to the closure of membrane _____ channels

Answer: Ca2+

Flashcard 1732: What drug class does propafenone belong to? _____

Answer: Class IC antiarrhythmics

Flashcard 1733: Cardiovascular (Antiarrhythmics) _____, a class III antiarrhythmic, has many neurologic side effects (e.g. tremor, ataxia, peripheral neuropathy, sleep disturbances)

Answer: Amiodarone

Flashcard 1734: Exogenous ADH is useful in the management of _____ bleeding by reducing portal hypertension (via action on V1 receptors)

Answer: esophageal variceal

Flashcard 1735: Which class of drugs is effective at reducing both nocturnal and meal-stimulated acid secretion, suppressing H+ secretion to a greater extent than H2 receptor blockers?

Answer: Proton pump inhibitors (PPIs)

Flashcard 1736: What class of autonomic drugs are contraindicated in cocaine toxicity? _____

Answer: Beta-blockers

Extra: Pure beta-blockers are contraindicated in cocaine toxicity due to the risk of **unopposed alpha-stimulation**. Blocking $\beta_2$-mediated vasodilation while $\alpha_1$-mediated vasoconstriction remains active can lead to severe hypertension and coronary artery vasoconstriction.

Flashcard 1737: Tetrodotoxin binds fast voltage-gated _____ channels in cardiac/nerve tissue, preventing depolarization

Answer: Na+

Flashcard 1738: What drug intoxication presents as pupillary dilation, grandiosity, vasospasm, and paranoia that lasts for less than one hour? _____

Answer: Cocaine

Flashcard 1739: Carcinoid syndrome may be treated with surgical resection or with a _____ analog

Answer: somatostatin

Flashcard 1740: What drug class does rivaroxaban and apixaban belong to?_____

Answer: Direct Xa inhibitors