Autonomic/CV Drugs — Flashcards

Flashcard 1711: What is the effect of M2 muscarinic agonists on heart rate? _____

Answer: Decreased HR (SA node)

Flashcard 1712: Oral bisphosphonates may cause _____ side effects

Answer: upper GI

Flashcard 1713: Which thioamide is contraindicated in the first trimester of pregnancy?_____

Answer: Methimazole, so need to use PTU

Flashcard 1714: Octreotide may cause _____ side effects

Answer: GI

Flashcard 1715: What drug class do amitriptyline and nortriptyline belong to?_____

Answer: Tricyclic antidepressants (TCAs)

Flashcard 1716: P-glycoprotein is found in the capillary endothelium of the _____ barrier

Answer: blood brain

Flashcard 1717: Labetalol causes vaso-_____

Answer: dilation

Flashcard 1718: Tetrodotoxin binds fast voltage-gated _____ channels in cardiac/nerve tissue, preventing depolarization

Answer: Na+

Flashcard 1719: One adverse effect associated with adenosine is cutaneous _____

Answer: flushing

Flashcard 1720: What class of autonomic drugs are contraindicated in cocaine toxicity? _____

Answer: Beta-blockers

Extra: Pure beta-blockers are contraindicated in cocaine toxicity due to the risk of **unopposed alpha-stimulation**. Blocking $\beta_2$-mediated vasodilation while $\alpha_1$-mediated vasoconstriction remains active can lead to severe hypertension and coronary artery vasoconstriction.