Autonomic/CV Drugs — Flashcards

Flashcard 1701: In addition to beta-blockers, essential tremor may also be treated with _____

Answer: primidone (a barbiturate)

Flashcard 1702: Treatment of a patent ductus arteriosus involves _____, which decreases PGE, resulting in PDA closure

Answer: indomethacin

Flashcard 1703: Evolocumab and alirocumab are lipid-lowering agents that inhibit _____

Answer: PCSK9 (what enzyme?)

Flashcard 1704: Decreased cAMP as a result of class II antiarrhythmics (beta-blockers) leads to the closure of membrane _____ channels

Answer: Ca2+

Flashcard 1705: One adverse effect associated with adenosine is cutaneous _____

Answer: flushing

Flashcard 1706: Cardiovascular (Antiarrhythmics) _____, a class III antiarrhythmic, has many neurologic side effects (e.g. tremor, ataxia, peripheral neuropathy, sleep disturbances)

Answer: Amiodarone

Flashcard 1707: What is the effect of M2 muscarinic agonists on heart rate? _____

Answer: Decreased HR (SA node)

Flashcard 1708: Tetrodotoxin binds fast voltage-gated _____ channels in cardiac/nerve tissue, preventing depolarization

Answer: Na+

Flashcard 1709: What class of autonomic drugs are contraindicated in cocaine toxicity? _____

Answer: Beta-blockers

Extra: Pure beta-blockers are contraindicated in cocaine toxicity due to the risk of **unopposed alpha-stimulation**. Blocking $\beta_2$-mediated vasodilation while $\alpha_1$-mediated vasoconstriction remains active can lead to severe hypertension and coronary artery vasoconstriction.

Flashcard 1710: Which class of drugs is effective at reducing both nocturnal and meal-stimulated acid secretion, suppressing H+ secretion to a greater extent than H2 receptor blockers?

Answer: Proton pump inhibitors (PPIs)