Autonomic/CV Drugs — Flashcards

Flashcard 1681: Acetazolamide is a _____ drug and thus may cause adverse reactions in allergic patients

Answer: sulfa

Flashcard 1682: Loperamide and diphenoxylate are μ-opioid agonists that can be used as anti-_____

Answer: diarrheals

Flashcard 1683: COX-_____ is inducible by inflammation

Answer: 2

Flashcard 1684: What phase of drug metabolism includes methylation, glucuronidation, acetylation, and sulfation (i.e. conjugation)? _____

Answer: Phase II

Flashcard 1685: What type of nerve fiber, myelinated or unmyelinated, is affected first by local anesthetics? _____

Answer: Myelinated fibers

Flashcard 1686: Thiazolidinedione-induced fluid retention can exacerbate _____

Answer: heart failure

Flashcard 1687: Which calcineurin inhibitor binds to FK506 binding protein (FKBP)? _____

Answer: Tacrolimus (FK506)

Flashcard 1688: The _____-opioid receptor mediates most of the clinical and adverse effects

Answer: Mu (μ)

Extra: Mu-opioid receptors are the primary mediators of the clinical effects (analgesia) and the majority of adverse effects (respiratory depression, constipation, and euphoria/addiction) associated with opioid drugs.

Flashcard 1689: _____ is the maximal effect a drug can produce

Answer: Efficacy

Flashcard 1690: What effect do anti-muscarinics have on heart rate? _____

Answer: Increased HR