Antimicrobials — Flashcards

Flashcard 831: _____ is an ER antagonist at breast and an agonist at bone and uterus

Answer: Tamoxifen

Flashcard 832: Lamotrigine is a _____ spectrum anti-epileptic

Answer: broad

Flashcard 833: Which of the antitumor antibiotics can cause alopecia?_____

Answer: All of them*

Flashcard 834: Iodine and iodophors work by _____ of DNA, RNA and proteins

Answer: halogenation

Flashcard 835: What is the treatment of early (blood-borne) Trypanosoma brucei infection?_____

Answer: Suramin

Flashcard 836: Which type of drug, ionized or uncharged, is cleared more quickly?_____

Answer: Ionized (trapped in urine)

Flashcard 837: Toxoid vaccines result in the production of anti-_____ antibodies

Answer: toxin

Flashcard 838: Which anti-scabies/louse therapy causes neuronal membrane depolarization?_____

Answer: Permethrin

Flashcard 839: Azathioprine/6-MP is associated with pancreatitis and _____-toxicity (organ)

Answer: hepato

Flashcard 840: Which enzymes are inhibited by cladribine?

Answer: DNA polymerase and ribonucleotide reductase

Extra: Cladribine is a purine (adenosine) analog that is resistant to adenosine deaminase. It is the drug of choice for hairy cell leukemia. It also causes DNA strand breaks.