Antimicrobials — Flashcards

Flashcard 831: Bleomycin is associated with skin toxicity, such as rash and _____

Answer: hyperpigmentation

Flashcard 832: Which enzymes are inhibited by cladribine?

Answer: DNA polymerase and ribonucleotide reductase

Extra: Cladribine is a purine (adenosine) analog that is resistant to adenosine deaminase. It is the drug of choice for hairy cell leukemia. It also causes DNA strand breaks.

Flashcard 833: Alemtuzumab is an antitumor monoclonal antibody that targets _____ of lymphocytes

Answer: CD52

Flashcard 834: What enzyme is inhibited by Hydroxyurea?_____

Answer: Ribonucleotide reductase

Flashcard 835: Which type of meningococcal vaccine (conjugate or polysaccharide) is currently recommended for adults > 55 years of age?

Answer: Conjugate vaccine

Flashcard 836: Which type of drug, ionized or uncharged, is cleared more quickly?_____

Answer: Ionized (trapped in urine)

Flashcard 837: Which anti-scabies/louse therapy causes neuronal membrane depolarization?_____

Answer: Permethrin

Flashcard 838: Azathioprine/6-MP is associated with pancreatitis and _____-toxicity (organ)

Answer: hepato

Flashcard 839: Which enzymes are inhibited by gemcitabine?

Answer: Ribonucleotide reductase and DNA polymerase

Flashcard 840: Which of the vinca alkaloids is more commonly used in Non-hodgkin's lymphoma?_____

Answer: Vincristine