Antimicrobials — Flashcards

Flashcard 831: Lamotrigine is a _____ spectrum anti-epileptic

Answer: broad

Flashcard 832: Azathioprine/6-MP is associated with pancreatitis and _____-toxicity (organ)

Answer: hepato

Flashcard 833: What enzyme is inhibited by Hydroxyurea?_____

Answer: Ribonucleotide reductase

Flashcard 834: Which enzymes are inhibited by gemcitabine?

Answer: Ribonucleotide reductase and DNA polymerase

Flashcard 835: Which type of meningococcal vaccine (conjugate or polysaccharide) is currently recommended for adults > 55 years of age?

Answer: Conjugate vaccine

Flashcard 836: Which anti-scabies/louse therapy causes neuronal membrane depolarization?_____

Answer: Permethrin

Flashcard 837: Iodine and iodophors work by _____ of DNA, RNA and proteins

Answer: halogenation

Flashcard 838: What is the treatment of early (blood-borne) Trypanosoma brucei infection?_____

Answer: Suramin

Flashcard 839: Which of the vinca alkaloids is more commonly used in Non-hodgkin's lymphoma?_____

Answer: Vincristine

Flashcard 840: Which enzymes are inhibited by cladribine?

Answer: DNA polymerase and ribonucleotide reductase

Extra: Cladribine is a purine (adenosine) analog that is resistant to adenosine deaminase. It is the drug of choice for hairy cell leukemia. It also causes DNA strand breaks.