Antimicrobials — Flashcards

Flashcard 821: What is an advantage of inactivated vaccines compared to live attenuated? _____

Answer: Inactivated vaccines are safer

Flashcard 822: 5-fluorouracil is a _____ analog

Answer: pyrimidine

Flashcard 823: What cell type is affected most by chemotherapy?_____

Answer: Labile (gut epithelium, skin, hair follicles, etc)

Flashcard 824: What type of vaccine is the acellular pertussis (aP) vaccine? _____

Answer: Subunit

Flashcard 825: Sorafenib has the ability to induce _____, which helps suppress tumor growth but can also cause drug resistance

Answer: autophagy

Flashcard 826: Chronic opioid use can cause opioid-induced _____, which is abnormal pain sensitivity

Answer: hyperalgesia

Flashcard 827: Which of the platinum analogs is most commonly associated with peripheral neuropathy?

Answer: Oxaliplatin

Extra: While all platinum analogs can cause peripheral neuropathy, it is the dose-limiting toxicity for **Oxaliplatin**. Oxaliplatin is characteristically associated with: 1. **Acute sensory neuropathy**: Triggered or exacerbated by exposure to cold. 2. **Chronic cumulative neuropathy**: Dose-dependent sensory loss. **Key Toxicities of Platinum Analogs:** * **Cisplatin**: Nephrotoxicity and Ototoxicity (most severe in this class). * **Carboplatin**: Myelosuppression (especially thrombocytopenia). * **Oxaliplatin**: Peripheral neuropathy.

Flashcard 828: Bleomycin is associated with skin toxicity, such as rash and _____

Answer: hyperpigmentation

Flashcard 829: _____ is folinic acid and does not require DHF reductase for the synthesis of thymidine

Answer: Leucovorin

Flashcard 830: In addition to cladribine (2-CDA), hairy cell leukemia may also be treated with _____

Answer: pentostatin