Combination antimicrobial therapy — Flashcards

Flashcard 1: In addition to increased risk for C. difficile infection, patients on proton pump inhibitors are also at increased risk for _____

Answer: pneumonia

Flashcard 2: What drugs are used in prophylaxis of toxoplasmosis (toxoplasma gondii)?_____

Answer: TMP/SMX

Flashcard 3: Isoniazid works to treat tuberculosis by inhibiting mycobacterial _____ production

Answer: Mycolic acid

Flashcard 4: Which antimicrobials displace unconjugated bilirubin from serum albumin in the blood?_____

Answer: Sulfonamides

Flashcard 5: What is the common treatment for all rickettsial diseases?

Answer: doxycycline

Flashcard 6: What are the two most characteristic toxicities associated with aminoglycosides?

Answer: Ototoxicity (Cranial Nerve VIII damage) and Nephrotoxicity

Flashcard 7: tetracyclines

Answer: discolored teeth

Flashcard 8: What is the mechanism of action of Antimycin A?

Answer: Inhibits Complex III of the Electron Transport Chain (ETC)

Extra: Antimycin A blocks the transfer of electrons from cytochrome b to cytochrome c1, effectively inhibiting the Electron Transport Chain and oxidative phosphorylation.

Flashcard 9: What is the mechanism of action of Cyanide?

Answer: Inhibits Cytochrome c oxidase (Complex IV) of the Electron Transport Chain, stopping oxidative phosphorylation.

Extra: Cyanide binds to the ferric (Fe3+) iron in cytochrome a3, preventing the final transfer of electrons to oxygen. Treatment: Nitrites (to create methemoglobin), Thiosulfate, or Hydroxocobalamin.

Flashcard 10: Mechanism of action of Rotenone?

Answer: Inhibits Complex I of the Electron Transport Chain (ETC)

Extra: Rotenone (pesticide), Amobarbital (barbiturate), and MPP+ inhibit Complex I. This prevents the transfer of electrons from NADH to Coenzyme Q, thereby inhibiting oxidative phosphorylation.