New antimicrobial development — Flashcards

Flashcard 1: Cyclophosphamide requires bioactivation by _____ enzymes to be effective

Answer: Cytochrome P450

Flashcard 2: Fluoroquinolones are _____ due to them causing cartilage damage to the fetus

Answer: teratogenic

Flashcard 3: Praziquantel is an anti-helminthic agent that increases Ca2+ permeability and increases _____.

Answer: vacuolization

Flashcard 4: DPP-4 inhibitors can increase risk of _____ tract infection

Answer: upper respiratory

Flashcard 5: What antimicrobial is similar to sulfonamides, inhibiting dihydropteroate synthase?_____

Answer: Dapsone

Flashcard 6: Toxoid vaccines are composed of a denatured bacterial toxin with an intact _____

Answer: receptor binding site

Flashcard 7: What is the common treatment for all rickettsial diseases?

Answer: doxycycline

Flashcard 8: What are the two most characteristic toxicities associated with aminoglycosides?

Answer: Ototoxicity (Cranial Nerve VIII damage) and Nephrotoxicity

Flashcard 9: tetracyclines

Answer: discolored teeth

Flashcard 10: What is the mechanism of action of Antimycin A?

Answer: Inhibits Complex III of the Electron Transport Chain (ETC)

Extra: Antimycin A blocks the transfer of electrons from cytochrome b to cytochrome c1, effectively inhibiting the Electron Transport Chain and oxidative phosphorylation.