Antimicrobials — Flashcards

Flashcard 811: Bleomycin is associated with skin toxicity, such as rash and _____

Answer: hyperpigmentation

Flashcard 812: Which two alkylating agents must be activated by CYP450 in the liver?_____

Answer: Cyclophosphamide, Ifosfamide

Flashcard 813: Which of the platinum analogs is most commonly associated with peripheral neuropathy?

Answer: Oxaliplatin

Extra: While all platinum analogs can cause peripheral neuropathy, it is the dose-limiting toxicity for **Oxaliplatin**. Oxaliplatin is characteristically associated with: 1. **Acute sensory neuropathy**: Triggered or exacerbated by exposure to cold. 2. **Chronic cumulative neuropathy**: Dose-dependent sensory loss. **Key Toxicities of Platinum Analogs:** * **Cisplatin**: Nephrotoxicity and Ototoxicity (most severe in this class). * **Carboplatin**: Myelosuppression (especially thrombocytopenia). * **Oxaliplatin**: Peripheral neuropathy.

Flashcard 814: What type of anemia results from methotrexate use?_____

Answer: Megaloblastic (macrocytic) anemia

Flashcard 815: Wuchereria bancrofti is treated with _____

Answer: diethylcarbamazine

Flashcard 816: Which anti-scabies/louse therapy inhibits Na+ channel deactivation?_____

Answer: Permethrin

Flashcard 817: What type of vaccine is the acellular pertussis (aP) vaccine? _____

Answer: Subunit

Flashcard 818: 5-fluorouracil is a _____ analog

Answer: pyrimidine

Flashcard 819: Which of the alkylating agents can cause neurotoxicity?_____

Answer: Nitrosoureas

Flashcard 820: _____ is an ER antagonist at breast and an agonist at bone and uterus

Answer: Tamoxifen