Antimicrobials — Flashcards

Flashcard 811: What type of vaccine is the acellular pertussis (aP) vaccine? _____

Answer: Subunit

Flashcard 812: Which of the platinum analogs is most commonly associated with peripheral neuropathy?

Answer: Oxaliplatin

Extra: While all platinum analogs can cause peripheral neuropathy, it is the dose-limiting toxicity for **Oxaliplatin**. Oxaliplatin is characteristically associated with: 1. **Acute sensory neuropathy**: Triggered or exacerbated by exposure to cold. 2. **Chronic cumulative neuropathy**: Dose-dependent sensory loss. **Key Toxicities of Platinum Analogs:** * **Cisplatin**: Nephrotoxicity and Ototoxicity (most severe in this class). * **Carboplatin**: Myelosuppression (especially thrombocytopenia). * **Oxaliplatin**: Peripheral neuropathy.

Flashcard 813: What is an advantage of inactivated vaccines compared to live attenuated? _____

Answer: Inactivated vaccines are safer

Flashcard 814: Which anti-scabies/louse therapy blocks GABA channels?_____

Answer: Lindane

Flashcard 815: _____ is folinic acid and does not require DHF reductase for the synthesis of thymidine

Answer: Leucovorin

Flashcard 816: What cell type is affected most by chemotherapy?_____

Answer: Labile (gut epithelium, skin, hair follicles, etc)

Flashcard 817: What type of anemia results from methotrexate use?_____

Answer: Megaloblastic (macrocytic) anemia

Flashcard 818: Which two alkylating agents must be activated by CYP450 in the liver?_____

Answer: Cyclophosphamide, Ifosfamide

Flashcard 819: What drugs (2) are used to treat toxoplasmosis (toxoplasma gondii)?_____

Answer: Pyrimethamine/Sulfadiazine

Flashcard 820: Which type of vaccine is a pathogen that has been inactivated by heat or chemicals? _____

Answer: Inactivated/killed vaccine