Antimicrobials — Flashcards

Flashcard 841: Which of the antitumor antibiotics can cause alopecia?_____

Answer: All of them*

Flashcard 842: Azathioprine/6-MP is associated with pancreatitis and _____-toxicity (organ)

Answer: hepato

Flashcard 843: Which type of drug, ionized or uncharged, is cleared more quickly?_____

Answer: Ionized (trapped in urine)

Flashcard 844: Once methotrexate enters the target cell, it undergoes _____, preventing the movement of MTX out of the cell

Answer: polyglutamation

Flashcard 845: Which enzymes are inhibited by cladribine?

Answer: DNA polymerase and ribonucleotide reductase

Extra: Cladribine is a purine (adenosine) analog that is resistant to adenosine deaminase. It is the drug of choice for hairy cell leukemia. It also causes DNA strand breaks.

Flashcard 846: The main side effect of the BCG vaccine is that it can cause _____ at the site of the injection

Answer: keloids

Flashcard 847: Which enzymes are inhibited by gemcitabine?

Answer: Ribonucleotide reductase and DNA polymerase

Flashcard 848: In addition to increased risk for C. difficile infection, patients on proton pump inhibitors are also at increased risk for _____

Answer: pneumonia

Flashcard 849: Azathioprine/6-MP have an _____ effect, hence why they are useful in the treatment of graft rejection, SLE, autoimmune hemolytic anemia, etc.

Answer: immunosuppressive

Flashcard 850: What is the treatment of choice for Naegleria fowleri?_____

Answer: Amphotericin B