Antimicrobials — Flashcards

Flashcard 511: 5-fluorouracil can be used topically to treat _____

Answer: basal cell carcinoma

Flashcard 512: 6-mercaptopurine (and thus azathioprine) are degraded by the enzyme _____

Answer: xanthine oxidase

Flashcard 513: What toxic intermediate is formed in small amounts by metabolism of acetaminophen? _____

Answer: NAPQI

Flashcard 514: Cladribine is a DNA polymerase inhibitor that treats _____ leukemia

Answer: hairy cell

Flashcard 515: Fomepizole works as an antidote for methanol/ethylene glycol poisoning by inhibiting _____

Answer: Alcohol Dehydrogenase

Flashcard 516: Ipilimumab is a checkpoint inhibitor that binds to _____ on T cells.

Answer: CTLA-4

Flashcard 517: What formula is used to calculate maintenance dose? _____

Answer: Maintenance dose = (Cp × CL × τ) / F

Extra: Cp = target plasma concentration at steady state CL = clearance τ = dosage interval F = bioavailability Note: Loading dose = (Cp × Vd) / F

Flashcard 518: Rituximab can lead to a depletion of what antibody type? _____

Answer: IgG

Flashcard 519: Rituximab binds CD20 of B-cells and tags it for natural killer cells via antibody-_____ cytotoxicity

Answer: dependent

Flashcard 520: Which antitumor monoclonal antibody is used to treat stage IV colorectal carcinoma (wild-type KRAS)?_____

Answer: Cetuximab