Antimicrobials — Flashcards

Flashcard 511: Sulfasalazine is contraindicated in patients with an allergy to _____ drugs

Answer: sulfa

Extra: Sulfasalazine is a DMARD used in the treatment of rheumatoid arthritis and inflammatory bowel disease. It is a combination of sulfapyridine (a sulfonamide) and 5-aminosalicylic acid (5-ASA). It is contraindicated in patients with a sulfonamide (sulfa) allergy. Etanercept, while also used for RA, is a TNF-alpha inhibitor and does not have this contraindication.

Flashcard 512: What is the most serious adverse effect associated with lamotrigine use?_____

Answer: Stevens-Johnson syndrome

Flashcard 513: Neutropenia may result from drug toxicity, especially _____

Answer: chemotherapy

Flashcard 514: Phase _____ of clinical trials uses a large number of patients randomly assigned either to a treatment under investigation or the best available treatment (or placebo)

Answer: III

Flashcard 515: Cladribine is a DNA polymerase inhibitor that treats _____ leukemia

Answer: hairy cell

Flashcard 516: Rituximab binds CD20 of B-cells and tags it for natural killer cells via antibody-_____ cytotoxicity

Answer: dependent

Flashcard 517: Which antitumor monoclonal antibody is used to treat stage IV colorectal carcinoma (wild-type KRAS)?_____

Answer: Cetuximab

Flashcard 518: 6-mercaptopurine (and thus azathioprine) are degraded by the enzyme _____

Answer: xanthine oxidase

Flashcard 519: Which antitumor monoclonal antibody targets HER2 (c-erbB2)?_____

Answer: trastuzumab (herceptin)

Flashcard 520: Rituximab can lead to a depletion of what antibody type? _____

Answer: IgG