Antimicrobials — Flashcards

Flashcard 501: Rituximab is a chimeric, monoclonal, Ig_____ antibody

Answer: G

Flashcard 502: Eculizumab is a monoclonal antibody for the _____ complement protein

Answer: C5

Flashcard 503: How should maintenance dose be adjusted in patients with renal or liver disease? _____

Answer: Decreased

Flashcard 504: Patients who are slow _____ have increased side effects from certain drugs due to decreased rate of metabolism

Answer: acetylators

Flashcard 505: What is the most serious adverse effect associated with lamotrigine use?_____

Answer: Stevens-Johnson syndrome

Flashcard 506: Mycophenolate mofetil is a powerful inhibitor of _____ proliferation (cell type)

Answer: lymphocyte (B and T cell)

Flashcard 507: Cladribine is a DNA polymerase inhibitor that treats _____ leukemia

Answer: hairy cell

Flashcard 508: Fomepizole works as an antidote for methanol/ethylene glycol poisoning by inhibiting _____

Answer: Alcohol Dehydrogenase

Flashcard 509: Ipilimumab is a checkpoint inhibitor that binds to _____ on T cells.

Answer: CTLA-4

Flashcard 510: What formula is used to calculate maintenance dose? _____

Answer: Maintenance dose = (Cp × CL × τ) / F

Extra: Cp = target plasma concentration at steady state CL = clearance τ = dosage interval F = bioavailability Note: Loading dose = (Cp × Vd) / F