Antimicrobials — Flashcards

Flashcard 521: What formula is used to calculate maintenance dose? _____

Answer: Maintenance dose = (Cp × CL × τ) / F

Extra: Cp = target plasma concentration at steady state CL = clearance τ = dosage interval F = bioavailability Note: Loading dose = (Cp × Vd) / F

Flashcard 522: 5-fluorouracil can be used topically to treat _____

Answer: basal cell carcinoma

Flashcard 523: 6-mercaptopurine is bioactivated into its active metabolites via the enzyme _____

Answer: HGPRT

Flashcard 524: Rituximab is associated with _____ and has been known to reactivate hepatitis B

Answer: immunosuppression

Flashcard 525: N-acetylcysteine helps restore _____ stores in the setting of acetaminophen toxicity

Answer: reduced glutathione

Flashcard 526: Which enzyme is inhibited by azathioprine/6-mercaptopurine?_____

Answer: PRPP amidotransferase

Flashcard 527: Administration of methotrexate results in a build-up of _____ in cells

Answer: DHF

Flashcard 528: "Busulfan Lung" is the term for the _____ pattern of lung damage which can be caused by Busulfan

Answer: fibrotic

Flashcard 529: Trichuris trichiura (whipworm) is treated with _____

Answer: albendazole

Flashcard 530: Ascaris lumbricoides is treated with _____

Answer: albendazole