Antimicrobials — Flashcards

Flashcard 521: Sulfasalazine is contraindicated in patients with an allergy to _____ drugs

Answer: sulfa

Extra: Sulfasalazine is a DMARD used in the treatment of rheumatoid arthritis and inflammatory bowel disease. It is a combination of sulfapyridine (a sulfonamide) and 5-aminosalicylic acid (5-ASA). It is contraindicated in patients with a sulfonamide (sulfa) allergy. Etanercept, while also used for RA, is a TNF-alpha inhibitor and does not have this contraindication.

Flashcard 522: Sargramostim is a recombinant form of _____

Answer: GM-CSF

Flashcard 523: Which chemotherapeutic drug is the most widely-used treatment of colorectal cancer?_____

Answer: 5-fluorouracil

Flashcard 524: 6-mercaptopurine is bioactivated into its active metabolites via the enzyme _____

Answer: HGPRT

Flashcard 525: Ascaris lumbricoides is treated with _____

Answer: albendazole

Flashcard 526: Trichuris trichiura (whipworm) is treated with _____

Answer: albendazole

Flashcard 527: Rituximab is associated with _____ and has been known to reactivate hepatitis B

Answer: immunosuppression

Flashcard 528: Ipilimumab and Pembrolizumab are monoclonal antibodies that work by downregulating _____ mechanisms*bonus: their respective targets:

Answer: immune tolerance Bonus (Targets): Ipilimumab: CTLA-4 Pembrolizumab: PD-1

Flashcard 529: Administration of methotrexate results in a build-up of _____ in cells

Answer: DHF

Flashcard 530: Which enzyme is inhibited by azathioprine/6-mercaptopurine?_____

Answer: PRPP amidotransferase