Antimicrobials — Flashcards

Flashcard 361: Paclitaxel (taxanes) inhibits mitotic spindle breakdown, which occurs in _____ of mitosis

Answer: anaphase*

Flashcard 362: _____ and arsenic are particularly mutagenic carcinogens found in cigarette smoke

Answer: Polycyclic aromatic hydrocarbons

Flashcard 363: Toxocara canis is treated with _____

Answer: albendazole

Flashcard 364: Cyclophosphamide is _____ by CYP450 in the liver

Answer: activated

Flashcard 365: Which of the platinum analogs is most commonly associated with myelosuppression? _____

Answer: Carboplatin

Flashcard 366: 5-fluorouracil is a prodrug that is converted to its active form _____

Answer: 5-fdUMP

Flashcard 367: A common side effect of all alkylating agents is _____

Answer: myelosuppression

Flashcard 368: Because the highly proliferative cell population at the bone marrow is very dependent on DNA synthesis, all antimetabolites (ex MTX, 5FU, Hydroxyurea) can cause _____

Answer: myelosuppression

Flashcard 369: Infliximab is a monoclonal antibody against _____

Answer: TNF-α

Extra: First Aid Pharmacology: Immunology

Flashcard 370: Which enzyme is inhibited by gemcitabine? _____

Answer: DNA polymerase (α and β)