Antimicrobials — Flashcards

Flashcard 371: Rituximab is associated with _____ and has been known to reactivate hepatitis B

Answer: immunosuppression

Flashcard 372: Hookworms (Ancylostoma duodenale, Necator americanus) are treated with _____ or albendazole

Answer: pyrantel pamoate

Flashcard 373: What compartment is the majority of a drug with high Vd found in? _____

Answer: All tissues including fat

Flashcard 374: Metronidazole is an antimicrobial that acts as an electron sink, creating _____ which disrupt _____ synthesis

Answer: free radicals

Flashcard 375: Cyclophosphamide attaches an alkyl group to the _____ of guanine

Answer: seventh nitrogen (N-7)

Flashcard 376: As two classes of antineoplastic agents that modulate microtubule structure, the distinction lies in that vinca-alkaloids prevent microtubule _____ whereas taxanes prevent microtubule _____

Answer: assembly

Flashcard 377: _____ and _____ directly inhibit PRPP amidotransferase, which normally catalyzes conversion of PRPP to 5-phosphoribosylamine (purine synthesis)

Answer: 6-mercaptopurine (6-MP)

Flashcard 378: Which NSAID is a sulfa drug? _____

Answer: Celecoxib

Flashcard 379: Palbociclib is a small molecular inhibitor of the _____ enzymes

Answer: CDK 4/6

Extra: #REF!

Flashcard 380: One treatment for cyanide poisoning is _____, which helps restore rhodanese-mediated metabolism of cyanide to thiocyanate

Answer: sodium thiosulfate

Extra: OnlineMedEd: Metabolism