Antimicrobials US Medical PG Flashcards - Medical Study Cards
Master Antimicrobials with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Antimicrobials Flashcard Deck - 10 Cards
Flashcard 351: Alemtuzumab is a monoclonal antibody against the cell surface marker CD52, which is expressed by _____
Answer: Lymphocytes
Extra:
https://onlinemeded.org/spa/immunology?ref=anki
Flashcard 352: Myelosuppression induced by Methotrexate / overdose can be reversed using the drug _____
Answer: Leucovorin
Extra: Leucovorin (folinic acid) is a reduced form of folic acid that bypasses dihydrofolate reductase (DHFR), the enzyme inhibited by Methotrexate. This allows for normal DNA synthesis to resume in healthy cells ("leucovorin rescue").
Flashcard 353: The amino acid _____ is essential for rapidly dividing tumor cells
Answer: asparagine
Extra:
https://onlinemeded.org/spa/dna-to-protein/amino-acids/acquire?ref=anki
Flashcard 354: Once methotrexate enters the target cell, it undergoes _____, preventing the movement of MTX out of the cell
Answer: polyglutamation
Extra:
Watch Methotrexate, leucovorin, 5 fluorouracil, hydroxyurea [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-antineoplastics/videos/medical-pharmacology-antineoplastics-antimetabolites-methotrexate-leucovorin-5-fluorouracil-hydroxyurea?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/dna-structure?index=10]
https://onlinemeded.org?ref=anki
Flashcard 355: _____ inhibits the enzyme dihydrofolate reductase in protozoa (pyrimidine synthesis)
Answer: Pyrimethamine
Extra:
https://onlinemeded.org/spa/metabolism?ref=anki
Flashcard 356: Mycophenolate mofetil can result in the hematological side effect of _____
Answer: myelosuppression
Extra:
https://onlinemeded.org/spa/immunology?ref=anki
Flashcard 357: Bleomycin acts as an antineoplastic by inducing _____ in DNA
Answer: single and double strand breaks
Extra:
https://onlinemeded.org?ref=anki
Flashcard 358: Metronidazole is a(n) _____ of CYP-450
Answer: inhibitor
Extra:
https://onlinemeded.org?ref=anki
Flashcard 359: What drug elimination is characterized by a constant amount of drug eliminated per unit time?
_____
Answer: Zero-order elimination
Extra:
https://onlinemeded.org?ref=anki
Flashcard 360: Paclitaxel (taxanes) inhibits mitotic spindle breakdown, which occurs in _____ of mitosis
Answer: anaphase*
Extra:
Watch Vincristine, vinblastine, paclitaxel [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-antineoplastics/videos/medical-pharmacology-antineoplastics-dna-and-cellular-division-vincristine-vinblastine-paclitaxel?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/mitosis-meiosis-and-the-cell-cycle?index=2]
https://onlinemeded.org?ref=anki
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