Antimicrobials — Flashcards

Ifosfamide is _____ by CYP450 in the liver

Quinolines are drugs that cause a build-up of _____ intracellularly, which is toxic to Plasmodium spp.

A toxoid is an inactivated bacterial _____-toxin used for vaccination

Hint: exo/endo

What class of drugs does lomustine belong to? _____

What antimicrobial is similar to sulfonamides, inhibiting dihydropteroate synthase? _____

What toxic intermediate is formed in small amounts by metabolism of acetaminophen? _____

What drug elimination is characterized by a constant fraction of drug eliminated per unit time? _____

Anthracyclines act as antineoplastics by producing _____ and causing DNA intercalation

One adverse effect of proton pump inhibitors (PPIs) is increased risk for _____ infection (2-3x increased risk)

Which of the alkylating agents can cause neurotoxicity (convulsions, dizziness, ataxia)? _____