Antimicrobials — Flashcards

Flashcard 121: Imatinib specifically inhibits the Bcr-Abl fusion protein by blocking the _____ portion

Answer: Abl

Flashcard 122: Sulfasalazine is activated by _____

Answer: colonic bacteria

Extra: First Aid Pharmacology: GI

Flashcard 123: Clavulanic acid, Sulbactam, and Tazobactam are what class of antimicrobial? _____

Answer: β-Lactamase Inhibitors

Extra: Beta-lactamase inhibitors (Clavulanic acid, Sulbactam, Tazobactam) are "suicide" inhibitors that bind to and inactivate β-lactamases, protecting the companion penicillin from degradation.

Flashcard 124: Which antitumor antibiotic drug solely intercalates into DNA? _____

Answer: Actinomycin D

Flashcard 125: What is the treatment for Clonorchis sinensis? _____

Answer: Praziquantel

Flashcard 126: What type of vaccine are the Meningococcal vaccines? _____

Answer: Subunit

Flashcard 127: _____ and _____ Anemia are rare hematological complications of propylthiouracil and methimazole use

Answer: Agranulocytosis

Extra: First Aid Pharmacology: Endocrine patient's on these drugs that develop a sore throat and fever should have their WBC count checked

Flashcard 128: Ifosfamide is _____ by CYP450 in the liver

Answer: activated

Flashcard 129: Quinolines are drugs that cause a build-up of _____ intracellularly, which is toxic to Plasmodium spp.

Answer: heme

Flashcard 130: Which enzyme is inhibited by cytarabine? _____

Answer: DNA polymerase (α and β)