Antimicrobials — Flashcards

Flashcard 141: Because the bone marrow is a rapidly proliferating population, use of 6-mercaptopurine (and thus azathioprine) is associated with _____

Answer: Myelosuppression

Flashcard 142: Sodium stibogluconate is used to treat all forms of _____

Answer: Leishmaniasis

Flashcard 143: Metronidazole is a(n) antimicrobial that contains a(n) _____ group allowing it to act as a(n) _____ sink

Answer: nitro

Flashcard 144: Metronidazole is used as treatment for which intestinal parasites? _____

Answer: Giardia; Entamoeba histolytica

Flashcard 145: Patients should not consume _____ while taking Metronidazole

Answer: alcohol

Flashcard 146: Dapsone can be used to treat the blistering skin disorder _____

Answer: Dermatitis Herpetiformis

Flashcard 147: Nifurtimox and Benznidazole are used to treat _____

Answer: Trypanosoma cruzi

Flashcard 148: In the process of bioactivating -phosphamides, a highly cytotoxic side product known as _____ is released which can cause Hemorrhagic Cystitis

Answer: Acrolein

Extra: Mesna (sodium 2-mercaptoethane sulfonate) and hydration are used to prevent hemorrhagic cystitis by neutralizing acrolein.

Flashcard 149: What drug inhibits dihydrofolate reductase in protozoa? _____

Answer: Pyrimethamine

Flashcard 150: Mycophenolate mofetil is used prophylactically to reduce _____

Answer: transplant rejection