Central Nervous System Pharmacology — Flashcards

Flashcard 61: Neuro/Psych _____ is an SNRI that is indicated for the treatment of fibromyalgia (musculoskeletal pathology)

Answer: Duloxetine

Flashcard 62: Antihistamines_____ generation H1 histamine receptor antagonists may be used to treat vestibular nausea and motion sickness

Answer: 1st

Flashcard 63: Which two inhibitory neurotransmitters have their release inhibited by Tetanospasmin? _____

Answer: GABA and glycine

Extra: Tetanospasmin cleaves synaptobrevin (SNARE protein) in Renshaw cells of the spinal cord, preventing the release of the inhibitory neurotransmitters GABA and glycine. This loss of inhibition leads to spastic paralysis, trismus (lockjaw), and risus sardonicus.

Flashcard 64: First Aid Pharmacology: Neuro/Psych Adverse effects associated with amantadine include _____ and livedo reticularis

Answer: ataxia

Flashcard 65: _____ is a selective 5-HT2A receptor inverse agonist that is approved for the management of delirium and hallucinations associated with Parkinson's disease

Answer: Pimavanserin

Flashcard 66: Neuro/Psych _____ and trihexyphenidyl are antimuscarinic agents used to treat Parkinsonism

Answer: Benztropine

Flashcard 67: As a result of inhibition of VDCCs (N-type Ca2+ channels) located on the _____ membrane of neurons, pregabalin results in decreased neurotransmission

Answer: presynaptic

Flashcard 68: Vortioxetine is a _____ receptor agonist

Answer: 5-HT1A

Flashcard 69: In addition to ethosuximide, absence seizures may also be treated with _____ and lamotrigine

Answer: valproic acid

Flashcard 70: _____ is an exotoxin from Clostridium tetani that cleaves SNARE proteins required for neurotransmitter release.

Answer: Tetanospasmin