Drugs of Abuse and Addiction — Flashcards

Flashcard 1: Neuro/Psych_____, barbiturates, and alcohol all bind different allosteric sites of the GABAA receptor

Answer: Benzodiazepines

Flashcard 2: Diphenhydramine and meclizine (1st generation H1 receptor blockers) may cause significant _____ and have significant anti-muscarinic properties

Answer: sedation

Flashcard 3: _____ subunit of the GABAA receptors produces sedation, anterograde amnesia and anticonvulsant action

Answer: Alpha-1 (α1)

Flashcard 4: _____ causes dissociative anesthesia.

Answer: Phencyclidine (Drug of abuse)

Flashcard 5: Intoxication of _____ shows a biphasic pattern

Answer: nicotine/tobacco

Flashcard 6: Cocaine intoxication can cause agitation, _____ (BP), tachycardia (HR), and pupillary dilation

Answer: hypertension

Flashcard 7: Adverse effects of gabapentin include _____ and ataxia

Answer: sedation

Flashcard 8: Dopamine inhibits the _____ basal ganglia pathway through D2 receptors

Answer: indirect

Flashcard 9: Sodium valproate mechanism of action: 1. Blocks voltage-gated _____ channels. 2. Increases the concentration of GABA in the brain. 3. Inhibits T-type calcium (Ca2+) channels.

Answer: sodium (Na+)

Extra: Sodium valproate is a broad-spectrum anticonvulsant used for generalized (including absence) and focal seizures. It increases GABA levels by inhibiting GABA transaminase and stimulating glutamic acid decarboxylase. It also inhibits T-type Ca2+ channels in the thalamus, which explains its efficacy in absence seizures.

Flashcard 10: The given plant is? _____

Answer: Erythroxylum coca