Antiepileptic Drugs — Flashcards

Flashcard 1: Less common but more serious side effects such as mood and behavioural changes are associated with _____

Answer: Levetiracetam (Anti-epileptic)

Flashcard 2: Neuro/Psych _____ is an anti-epileptic associated with gingival hyperplasia

Answer: Phenytoin

Flashcard 3: _____ is the drug of choice for myoclonic seizures.

Answer: Sodium valproate

Flashcard 4: The side effects of ethosuximide may be remembered with the letters of the alphabet "EFGHIJ": E: Ethosuximide F: _____ G: GI distress H: Headache I: Itching/urticaria J: Stevens-Johnson syndrome

Answer: Fatigue

Flashcard 5: Drug of choice for tonic-clonic seizures is ?

Answer: Sodium valproate

Flashcard 6: benzodiazepines, such as _____ and diazepam, are the 1st-line agents for treatment for acute status epilepticus

Answer: lorazepam

Flashcard 7: Drug of choice for myoclonic epilepsy in pregnancy is :

Answer: Levetiracetam

Flashcard 8: Sodium valproate mechanism of action: 1. Blocks voltage-gated _____ channels. 2. Increases the concentration of GABA in the brain. 3. Inhibits T-type calcium (Ca2+) channels.

Answer: sodium (Na+)

Extra: Sodium valproate is a broad-spectrum anticonvulsant used for generalized (including absence) and focal seizures. It increases GABA levels by inhibiting GABA transaminase and stimulating glutamic acid decarboxylase. It also inhibits T-type Ca2+ channels in the thalamus, which explains its efficacy in absence seizures.

Flashcard 9: The given plant is? _____

Answer: Erythroxylum coca

Flashcard 10: tetanospasmin blocks _____

Answer: presynaptic inhibitory neurotransmitter release

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