Local Anesthetics — Flashcards

Flashcard 1: _____ is the most potent, most toxic and longest acting local anaesthetic agent

Answer: Dibucaine

Flashcard 2: Local anesthetics exert their actions by blocking _____-gated Na+ channels (via binding to specific receptors on the inner portion of the channel), showing a preference for activated or inactivated states.

Answer: voltage

Flashcard 3: Sodium valproate mechanism of action: 1. Blocks voltage-gated _____ channels. 2. Increases the concentration of GABA in the brain. 3. Inhibits T-type calcium (Ca2+) channels.

Answer: sodium (Na+)

Extra: Sodium valproate is a broad-spectrum anticonvulsant used for generalized (including absence) and focal seizures. It increases GABA levels by inhibiting GABA transaminase and stimulating glutamic acid decarboxylase. It also inhibits T-type Ca2+ channels in the thalamus, which explains its efficacy in absence seizures.

Flashcard 4: The given plant is? _____

Answer: Erythroxylum coca

Flashcard 5: tetanospasmin blocks _____

Answer: presynaptic inhibitory neurotransmitter release

Extra: 

Flashcard 6: The three nonbenzodiazepine hypnotics are _____, Zaleplon, and esZopiclone

Answer: Zolpidem

Flashcard 7: Valproic acid exerts its effects by increasing _____ channel inactivation and inhibiting GABA transaminase

Answer: Na+

Flashcard 8: Vortioxetine is a _____ receptor antagonist

Answer: 5-HT3

Flashcard 9: Neuro/Psych _____ is an anti-epileptic that may be used to treat post-herpetic neuralgia

Answer: Gabapentin

Flashcard 10: Baclofen exerts its effects by _____ of GABAB receptors at the spinal cord level, causing muscle relaxation

Answer: activation