Antiparkinsonian Drugs — Flashcards

Flashcard 1: The _____ receptor antagonism of amantadine is responsible for its antidyskinetic properties in parkinsonism

Answer: NMDA glutamate

Flashcard 2: Which reversible MAO-B inhibitor is used for the management of On-off phenomenon in Parkinson's treatment?_____

Answer: Safinamide

Flashcard 3: Drug of choice in drug induced parkinsonism is:

Answer: Anticholinergics

Flashcard 4: Trihexyphenidyl and benztropine are useful for treating the _____ and rigidity of Parkinson disease

Answer: tremor

Flashcard 5: Neuro/Psych _____ and trihexyphenidyl are antimuscarinic agents used to treat Parkinsonism

Answer: Benztropine

Flashcard 6: Which dopamine receptor agonist is associated with antioxidant effect?_____

Answer: Pramipexole

Flashcard 7: Neuro/Psych _____ is a peripheral DOPA decarboxylase inhibitor used to increase the bioavailability of levodopa

Answer: Carbidopa

Flashcard 8: Dopamine inhibits the _____ basal ganglia pathway through D2 receptors

Answer: indirect

Flashcard 9: Sodium valproate mechanism of action: 1. Blocks voltage-gated _____ channels. 2. Increases the concentration of GABA in the brain. 3. Inhibits T-type calcium (Ca2+) channels.

Answer: sodium (Na+)

Extra: Sodium valproate is a broad-spectrum anticonvulsant used for generalized (including absence) and focal seizures. It increases GABA levels by inhibiting GABA transaminase and stimulating glutamic acid decarboxylase. It also inhibits T-type Ca2+ channels in the thalamus, which explains its efficacy in absence seizures.

Flashcard 10: The given plant is? _____

Answer: Erythroxylum coca