Central Nervous System Pharmacology — Flashcards

Flashcard 191: Opioids such as meperidine, tramadol, fentanyl and _____ block neuronal uptake of serotonin and can cause Serotonin syndrome

Answer: dextromethorphan

Flashcard 192: _____ is FDA approved for the treatment of ALS with SOD1 mutation

Answer: Tofersen

Flashcard 193: Use of reserpine results in low levels of _____

Answer: Dopamine, norepinephrine, and serotonin (monoamines)

Flashcard 194: Vigabatrin acts by irreversibly blocking the _____ to increase GABA action.

Answer: GABA transaminase

Flashcard 195: Valproate is _____ used as a first line drug in the treatment of focal seizures with intact awareness

Answer: not

Flashcard 196: _____ is a 5-HT1F receptor agonist used for acute attacks of migraine and can be used in patients with CAD

Answer: Lasmiditan

Flashcard 197: Drug of choice for essential tremors

Answer: Propranolol

Flashcard 198: Drug of choice for Huntington's chorea is

Answer: Tetrabenazine

Extra: VMAT2 inhibitors (Tetrabenazine, Deutetrabenazine) are the current drugs of choice for managing chorea in Huntington's disease. Haloperidol (a D2 receptor antagonist) is an alternative and was traditionally considered the DOC, particularly when psychiatric symptoms are co-present.

Flashcard 199: Drug of choice for treatment of Alzheimer's disease is:

Answer: Donepezil

Flashcard 200: Drug of choice in acute severe migraine is:

Answer: Sumatriptan