Central Nervous System Pharmacology — Flashcards

Flashcard 191: Vigabatrin acts by irreversibly blocking the _____ to increase GABA action.

Answer: GABA transaminase

Flashcard 192: The best drug for long-term preventive therapy for SUNCT/SUNA is _____.

Answer: lamotrigine

Flashcard 193: Opioids such as meperidine, tramadol, fentanyl and _____ block neuronal uptake of serotonin and can cause Serotonin syndrome

Answer: dextromethorphan

Flashcard 194: _____ is FDA approved for the treatment of ALS with SOD1 mutation

Answer: Tofersen

Flashcard 195: _____ is a selective H3 receptor inverse agonist used in the treatment of Narcolepsy.

Answer: Pitolisant

Extra: Pitolisant (formerly known as tiprolisant) is a selective H3-receptor inverse agonist. By blocking presynaptic H3 autoreceptors, it increases the synthesis and release of histamine, a wake-promoting neurotransmitter. It is used for the treatment of excessive daytime sleepiness (EDS) and cataplexy in patients with narcolepsy.

Flashcard 196: _____ is a 5-HT1F receptor agonist used for acute attacks of migraine and can be used in patients with CAD

Answer: Lasmiditan

Flashcard 197: Drug of choice for tonic-clonic seizures is ?

Answer: Sodium valproate

Flashcard 198: Drug of choice for drug induced parkinsonism?

Answer: Anticholinergics

Flashcard 199: _______ is the drug of choice for myoclonic seizures.

Answer: Sodium valproate

Flashcard 200: Drug of choice for acute severe migraine is

Answer: Triptans