Central Nervous System Pharmacology — Flashcards

Flashcard 181: Cocaine inhibits the reuptake of which neurotransmitters?_____

Answer: Dopamine, Norepinephrine and Serotonin

Flashcard 182: Which GABA receptor is metabotropic?_____

Answer: GABA B

Flashcard 183: Betahistine is a H1 receptor _____ used in Meniere's disease

Answer: agonist

Flashcard 184: Which drugs are pure opioid antagonists?_____

Answer: Naloxone, naltrexone and Nalmefene (3)

Flashcard 185: Mechanism of action of MgSO4: Potentiation of _____ action

Answer: adenosine (neurotransmitter)

Flashcard 186: What is the botanical name of the plant from which cocaine is derived?

Answer: Erythroxylum coca

Extra: The plant Erythroxylum coca (family Erythroxylaceae) is the primary source of the alkaloid cocaine, which acts as a potent CNS stimulant and local anesthetic.

Flashcard 187: Which amide local anesthetic has the fastest onset of action?

Answer: Mepivacaine

Flashcard 188: _____ is the drug of choice for infantile spasms associated with tuberous sclerosis.

Answer: Vigabatrin

Flashcard 189: _____ is a selective H3 receptor inverse agonist used in the treatment of Narcolepsy.

Answer: Pitolisant

Extra: Pitolisant (formerly known as tiprolisant) is a selective H3-receptor inverse agonist. By blocking presynaptic H3 autoreceptors, it increases the synthesis and release of histamine, a wake-promoting neurotransmitter. It is used for the treatment of excessive daytime sleepiness (EDS) and cataplexy in patients with narcolepsy.

Flashcard 190: Valproate is _____ used as a first line drug in the treatment of focal seizures with intact awareness

Answer: not