Cholinergic/Adrenergic drugs — Flashcards

Flashcard 391: Which drug class is used to reverse the effects of neuromuscular junction blockade?_____

Answer: Acetylcholinesterase inhibitors (e.g. neostigmine)

Flashcard 392: Adverse effects of paroxetine include anti-_____ effects and weight gain

Answer: cholinergic

Extra: Paroxetine is the SSRI most associated with anticholinergic side effects (e.g., dry mouth, constipation) and weight gain. This contrasts with newer agents like vilazodone, which are generally weight-neutral and have minimal anticholinergic activity.

Flashcard 393: What is the first line treatment for partial (focal) seizures? _____

Answer: Carbamazepine

Flashcard 394: Trazodone is an _____-adrenergic antagonist

Answer: α1 (Alpha-1)

Extra: Trazodone's α1-adrenergic antagonism is responsible for side effects such as orthostatic hypotension and priapism (mnemonic: trazoBONE).

Flashcard 395: What effect does atropine have on the gut motility?_____

Answer: Decreased motility

Flashcard 396: Aging of the organophosphate-cholinesterase complex leads to _____ binding

Answer: irreversible

Flashcard 397: What is the effect of M2 muscarinic agonists on heart contractility? _____

Answer: Decreased atrial contractility

Flashcard 398: Stimulants (e.g. amphetamine, methylphenidate) may _____ appetite

Answer: suppress

Flashcard 399: Pancuronium, vecuronium, and rocuronium are _____ (depolarizing or non-depolarizing) neuromuscular blocking agents

Answer: non-depolarizing

Flashcard 400: Pharmacological treatment for intractable and distressing tics in Tourette syndrome may include _____-adrenergic agonists

Answer: Alpha-2