Autonomic/CV Drugs — Flashcards

Flashcard 771: Which PDE-5 inhibitor may be used to treat BPH? _____

Answer: Tadalafil

Flashcard 772: What is the formula for calculating **loading dose**?

Answer: Loading dose = (Cp × Vd) / F Cp = target plasma concentration Vd = volume of distribution F = bioavailability

Extra: Loading dose is primarily dependent on the **volume of distribution** (Vd). For a drug given IV, F = 1. In contrast, maintenance dose is primarily dependent on **clearance** (CL).

Flashcard 773: _____ is a substance found in many aged foods (e.g. cheese, meats, alcohol)

Answer: Tyramine

Extra: Sketchy Pharmacology: Neuro/Psych

Flashcard 774: PDE-5 inhibitors (e.g. sildenafil, tadalafil) are indicated for _____ hypertension

Answer: pulmonary

Flashcard 775: Platinum based antineoplastics can cause side effects which might make ya say NOPE - N_____, in particular _____ - Ototoxicity - Peripheral Neuropathy - Emesis

Answer: ephrotoxicity

Flashcard 776: Compared to unfractionated heparin, LMWH and fondaparinux are _____ likely to cause HIT

Answer: less

Flashcard 777: Aspirin is an NSAID that is associated with _____ as an adverse effect

Answer: tinnitus

Flashcard 778: _____ agonists can cause opioid withdrawal symptoms if the patient is also taking a full opioid agonist

Answer: Partial opioid

Extra: Sketchy Pharmacology: Neuro/Psych

Flashcard 779: In the treatment of Multiple Sclerosis, Natalizumab works by preventing extravasation of autoreactive _____ T Cells

Answer: CD4+

Flashcard 780: Which kinase inhibitor can be used to treat non-small cell lung cancer due to EGFR overexpression? _____

Answer: Erlotinib