Autonomic/CV Drugs — Flashcards

Flashcard 511: The effect of aspirin on coagulation studies is _____

Answer: increased bleeding time, no change in PT and PTT

Extra:    https://onlinemeded.org/spa/heme-onc/hemostasis/acquire?ref=anki 

Flashcard 512: Bradykinin causes vaso-_____ and _____ vascular permeability

Answer: dilation

Extra:  https://onlinemeded.org/spa/heme-onc/hemostasis/acquire?ref=anki 

Flashcard 513: The goal INR for warfarin therapy is typically between _____ - _____

Answer: 2

Extra:   Watch Warfarin [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-blood-inflammation/videos/medical-pharmacology-blood-and-inflammation-anticoagulants-and-thrombolytics-warfarin?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/hematology-and-oncology/videos/coagulation-and-fibrinolysis?index=11] https://onlinemeded.org/spa/heme-onc/hemostasis/acquire?ref=anki 

Flashcard 514: Aspirin may cause a "pseudo-allergy" due to excess _____ synthesis

Answer: leukotriene

Extra:   Watch Antiplatelet agents [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-blood-inflammation/videos/medical-pharmacology-blood-and-inflammation-anticoagulants-and-thrombolytics-antiplatelet-agents?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/hematology-and-oncology/videos/platelets?index=10] https://onlinemeded.org/spa/heme-onc/hemostasis/acquire?ref=anki  Aspirin-Exacerbated Respiratory Disease - ↑ LOX pathway when COX blocked. - this is a non-IgE-mediated reaction (pseudo-allergic reaction); treatment includes avoidance of NSAIDs and/or administration of leukotriene receptor antagonists (e.g. montelukast) 

Flashcard 515: Histamine causes _____ of bronchial smooth muscle, especially in patients with asthma (H1 receptor activation)

Answer: constriction

Extra:   Sketchy Pharmacology: Respiratory (Antihistamines) Watch Antihistamines [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-smooth-muscle/videos/medical-pharmacology-smooth-muscle-allergy-and-pulmonary-antihistamines?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/immunology/videos/hypersensitivities?index=2] https://onlinemeded.org/spa/general-physiology/smooth-muscle/acquire?ref=anki 

Flashcard 516: What class of diabetic drugs is associated with increased risk of fracture as a possible side effect? _____

Answer: Thiazolidinediones (glitazones)

Extra:   Sketchy Pharmacology: Endocrine (diabetes) Watch Metformin, thiazolidinediones, pramlintide, SGLT2 inhibitors [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-gi-endocrine/videos/medical-pharmacology-gi-and-endocrine-diabetes-metformin-thiazolidinediones-pramlintide-sglt2-inhibitors?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/surgery-general/pancreas/acquire?ref=anki 

Flashcard 517: Commonly associated drugs with DRESS syndrome include _____, carbamazepine, allopurinol, sulfonamides

Answer: phenytoin

Extra:  https://onlinemeded.org?ref=anki 

Flashcard 518: Inhibition of COX-1 by NSAIDs leads to _____ bleeding time

Answer: increased

Extra:   Watch NSAIDs [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-blood-inflammation/videos/medical-pharmacology-blood-and-inflammation-anti-inflammatory-nsaids?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/hematology-and-oncology/videos/platelets?index=10] https://onlinemeded.org/spa/heme-onc/hemostasis/acquire?ref=anki 

Flashcard 519: Adverse effects of sirolimus (rapamycin) include _____ and insulin resistance

Answer: pancytopenia

Flashcard 520: Spironolactone may have anti-androgenic effects via direct antagonism of the _____ receptor

Answer: androgen

Extra:   Sketchy Pharmacology: Renal (Diuretics) Watch K+ sparing diuretics [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-cardiovascular-renal/videos/medical-pharmacology-cardiovascular-and-renal-diuretics-k-sparing-diuretics?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/endocrinology?ref=anki